Biological Inorganic Chemistry: An Introduction

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Elsevier, Dec 11, 2007 - Science - 381 pages
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The importance of metals in biology, the environment and medicine has become increasingly evident over the last twenty five years. The study of the multiple roles of metal ions in biological systems, the rapidly expanding interface between inorganic chemistry and biology constitutes the subject called Biological Inorganic Chemistry. The present text, written by a biochemist, with a long career experience in the field (particularly iron and copper) presents an introduction to this exciting and dynamic field. The book begins with introductory chapters, which together constitute an overview of the concepts, both chemical and biological, which are required to equip the reader for the detailed analysis which follows. Pathways of metal assimilation, storage and transport, as well as metal homeostasis are dealt with next. Thereafter, individual chapters discuss the roles of sodium and potassium, magnesium, calcium, zinc, iron, copper, nickel and cobalt, manganese, and finally molybdenum, vanadium, tungsten and chromium. The final three chapters provide a tantalising view of the roles of metals in brain function, biomineralization and a brief illustration of their importance in both medicine and the environment.

Relaxed and agreeable writing style. The reader will not only fiind the book easy to read, the fascinating anecdotes and footnotes will give him pegs to hang important ideas on.

Written by a biochemist. Will enable the reader to more readily grasp the biological and clinical relevance of the subject.

Many colour illustrations. Enables easier visualization of molecular mechanisms

Written by a single author. Ensures homgeneity of style and effective cross referencing between chapters
 

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Contents

Chapter 1 An Overview of Metals in Biology
1
Chapter 2 Basic Coordination Chemistry for Biologists
13
Chapter 3 Biological Ligands for Metal Ions
27
Chapter 4 Structural and Molecular Biology for Chemists
43
Chapter 5 An Overview of Intermediary Metabolism and Bioenergetics
77
Chapter 6 Methods to Study Metals in Biological Systems
105
Chapter 7 Metal Assimilation Pathways
117
Chapter 8 Transport Storage and Homeostasis of Metal Ions
131
Lewis Acid and Gene Regulator
197
Essential for Almost All Life
211
Coping with Dioxygen
241
Evolutionary Relics
257
Water Splitting Oxygen Atom Donor
271
Chapter 17 Molybdenum Tungsten Vanadium and Chromium
279
Chapter 18 Metals in Brain and Their Role in Various Neurodegenerative Diseases
297
Chapter 19 Biomineralization
321

Chapter 9 Sodium and PotassiumChannels and Pumps
151
Chapter 10 MagnesiumPhosphate Metabolism and Photoreceptors
165
Cellular Signalling
183
Chapter 20 Metals in Medicine and the Environment
339
Index
353
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About the author (2007)

Unité de Biochimie, Université Catholique de Louvain, Louvain-la-Neuve, Belgium
Prof. Crichton, originally from the UK, is well known in the inorganic biology community and is invited to speak at many international conferences. He has published 3 books in this area (others on biochemistry of iron and metal-based neruodegeneration) and has taught over 750 doctoral and post-doctoral students. The book contains an essential distillation of the knowledge and material he had used to teach and lecture over many years.

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