Biological Reactive Intermediates Vi: Chemical and Biological Mechanisms in Susceptibility to and Prevention of Environmental Diseases
Patrick Dansette, Robert R. Snyder, Terrence J. Monks, David J. Jollow, I. Glenn Sipes, Helmut Greim, G. Gordon Gibson, Marcel Delaforge
Springer Science & Business Media, Nov 30, 2001 - Science - 728 pages
Historically we have separated the disciplines of Chemistry and Biochemistry by recognizing that the distinguishing characteristic of Biochemistry is the catalysis of reactions by enzymes. Enzymes permit metabolic reactions which would otherwise require extremes of temperature, pressure or pH, often associated with Chemistry, to proceed under ambient conditions of the body. Under some conditions chemical reactions occur in vivo in which products of enzymatic reactions proceed to undergo further reactions non enzymatically with cellular macromolecules. The results can often be seen as toxic or carcinogenic responses. The chemicals that initiate these reactions are termed "biological reactive intermediates. " The International Symposia on Biological Reactive Intermediates (BRI) began in 1975 at the University of Turku, Finland and have since convened at the University of Surrey, Guildford, The United Kingdom (1980), the University of Maryland, College Park, Maryland (1985), the University of Arizona, Tucson, Arizona (1990), the GSF Forschungszentrum and Technical University of Munich (1995) and, most recently, at the Universite Rene Descartes, Paris, France (2000). The Symposium was organized by an International Planning Committee co-chaired by P. Dansette (Paris, France) and TJ. Monks (Austin, Texas). The committee included: P. H. Beaune (Paris, France), M. De\aforge (Saclay, France), G. P. Gervasi (Pisa, Italy), G. G. Gibson (Guildford, UK), H. Greim (Munich, Germany), DJ. Jollow (Charleston, South Carolina), P. Moldeus (Sodertalje, Sweden), I. G. Sipes (Tucson, Arizona), R. Snyder PJ. van Bladderen (Zeist, The Netherlands). They were (Piscataway, New Jersey), and assisted by an International Scientific Program Advisory Committee which included: TJ.
What people are saying - Write a review
We haven't found any reviews in the usual places.
Other editions - View all
acid activity aflatoxin analysis animals antioxidant apoptosis benzene binding bioactivation Biochem Biol Biological Reactive Intermediates brain cancer carcinogenesis carcinogenic caspase catalyzed cell death cellular Chem chemical compounds concentrations conjugates covalent cysteine cytochrome P450 cytotoxicity damage Dansette Dansette etal decreased detected DNA adducts dose drug Edited by Dansette effects enzyme epoxide hydrolase estrogen exposure expression extracellular factor Figure flavonoids formation formed function gene glutathione glutathione S-transferase Guengerich hepatic hepatocytes hydrolysis hydroxyl inactivation increased incubated induced inhibition inhibitor interaction levels lipid peroxidation liver microsomes lung mechanism membrane metabolism metabolites mice mitochondrial molecular mouse mutagenic mutations NADPH neuronal neurotoxicity nitric oxide observed oxidative stress P-glycoprotein pathway peroxynitrite Pharmacol potential protein quercetin quinone reaction Reactive Intermediates reactive metabolites receptor redox reduced reductase renal residues role S-transferase specific structure studies substrate superoxide target tissue toxicity Toxicol Toxicology tumor tyrosine vitro vivo