Biological effects of heavy metals, Volume 1
This text addresses the increasingly critical problems of heavy metals as toxic pollutants in the environment. The contents of this volume are based on a symposium held by the Society of Toxicology in 1987. Chapters discuss the strong evidence that a common denominator in the action of many toxicants in the nervous system is the interference with Ca homeostasis. Other topics address neuropathological effects of various metals, neurobehavioral aspects of toxicology, and the effects of metals on a specific sensory system, the retina. The use of heavy metals in experiments to elucidate the mechanisms of normal physiological functions is well illustrated in these chapters. Emphasis is in experimental technique to study how metals interact with specific portions of the nervous system. This review addresses the serious health effects and environmental pollution of heavy metal exposure. It is valuable reading for neurophysiologists, neurochemists, neuropharmacologists, and students of development and bahavior. This is an important resource book also for toxicologists, biochemists, nutritionists, and students of biological processes.
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Effects of Chronic In Vivo Heavy Metal Exposure on Calcium Channels
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acid activity acute adult alterations aluminum ATPase axons b-wave behavioral binding Biochem Ca2+ channels Ca2+ concentration cadmium calcium channels calmodulin Cd2+ cerebral changes chloride chronic cortex cytoplasmic damage decrease deficits degeneration depolarization depolarization-evoked edema effects of TET effects of triethyltin efflux electrophysiological enzyme evoked experimental function granule cells heavy metals Hg2+ hippocampus induced inhibition interaction intoxication intracellular intramyelinic intraterminal Ca2+ ions lead exposure lead-exposed rats levels limbic system mechanisms MeHg+ mercury metabolism methylmercury mg/kg mice mitochondria myelin neonatal nerve terminal nervous system Neurobehav Neurochem neuromuscular junction neurons Neuropathol neuropathology neurotoxic Neurotoxicology neurotransmitter observed organotin compounds oxidative oxidative phosphorylation Pb2+ Pharmacol phosphorylation photoreceptor Physiol post-treatment postnatal potential presynaptic protein pyramidal cells rat brain receptor reported retina rhodopsin seizure sensitivity spontaneous transmitter release stimulation studies suggest synaptic synaptosomes Teratol TET exposure TET-induced tissue toxicity Toxicol trialkyltin uptake vacuolation vitro vivo