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ACTH action activity administration adrenal adrenergic affective disorders amino acids amphetamine animals antidepressant antipsychotic Arch barbiturates behavior biochemical bipolar blood bufotenine Bunney catecholamines cause cells changes chlorpromazine chronic Clin clinical compounds correlation corticoids decrease depressed patients derivatives disease dopamine dosage doses drugs edited enzyme epinephrine excretion factors function genetic glucocorticoids glucose hallucinogenic Himwich hormone hydroxylase illness imipramine increased inhibition inhibitor levels lithium manic maturation mechanism mental mescaline metabolism metabolites methionine methyl monoamine morphine myelin nervous system Neurochem neurons norepinephrine normal occur pattern Pharmacol pharmacological phenothiazines phenylethylamine physiologic placebo plasma concentrations produce protein psychologic psychosis psychotomimetic rat brain receptor release reported reserpine response schizo schizophrenia sensory serotonergic serotonin side effects sleep Smythies sodium specific stimulation stress stressors studies suggested symptoms syndrome synthesis therapeutic thioridazine tion tissue tolerance transmitter treatment tricyclic tryptamine tryptophan twins tyrosine unipolar unipolar depressed uptake urinary urine York