Biological Response Modifiers — Interferons, Double-Stranded RNA and 2′,5′-Oligoadenylates
W.E.G. Müller, H.C. Schröder
Springer Berlin Heidelberg, Apr 21, 1994 - Science - 275 pages
Biological response modifiers are increasingly used in viral and cancer therapy. Since alterations of the immune system are the primary symptoms of HIV infection, especially therapies directed towards the modulation of the immune response have been under intense evaluation. This volume summarizes current knowledge of the interferon-based natural antiviral protection system including 2',5'-oligoadenylate and double-stranded RNA. It will also help to develop further a solid scientific rationale for the practical use of heterologous immunomodulators in the clinics.
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DoubleStranded RNAs as Gene Activators
ViralDependent Phosphorylation of a dsRNADependent
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Biological Response Modifiers — Interferons, Double-Stranded RNA and 2′,5 ...
W.E.G. Müller,H.C. Schröder
No preview available - 2011
2-5A synthetase 2',5'-oligoadenylate synthetase 3T3 cells Acad Sci USA adenovirus ampligen analogues antibodies antigen antiviral antiviral activity autophosphorylation Baglioni BB rats binding Biochem Biol Chem cAMP cAMP-dependent cellular Charubala cordycepin cytokines decrease degradation diabetes DNA topoisomerase double-stranded RNA dsRNA dsRNA-dependent dsſ dyes effect enhancement enzyme function Galabru gene expression HIV-infected Hovanessian human immunodeficiency virus IFN-X induced infected cells inhibition inhibitor interaction intercalating interferon Interferon Res interferon-induced intracellular Katze MG kinase activity levels lymphocytes macrophages mechanism mediated molecular molecules monocytes mRNA Müller WEG Natl Acad Sci NF-kB nuclear nucleotide oligoadenylate ºr ºr ºr P68 kinase pathway Petryshyn Pfeffer Pfleiderer phosphorothioate phosphorylation poly r(A-U poly(I Proc Natl Acad production protein kinase protein synthesis receptor regulation regulatory RN25ASYN RNase RNase L role Schröder HC sequence Suhadolnik RJ T-cells Tat protein tissues transcription treatment trimer viral Virol Virology virus infection viruses vitro Williams BRG