Biology, Toxicology and Carcinogenesis of Respiratory Epithelium

Front Cover
G. Thomassen
CRC Press, Dec 1, 1989 - Medical - 308 pages

This broadly-based reference resource was compiled as a result of the rapid rise in lung cancer incidence among the world's industrialized nations. Leading researchers address modern research on the respiratory epithelium.

 

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Contents

Biology of Respiratory Epithelium
1
Composition Differentiation and Response to Hormones
6
In Vivo Composition Differentiation and Response to Hormones
24
The Functions of Pulmonary Clara Cells
38
Growth and Differentiation of Pulmonary Alveolar Epithelial Cells
60
Markers for Differentiated Alveolar Cells
67
Identification of Multiple Stages in the Program of Squamous Differentiation in Tracheobronchial
74
Epithelial Progenitor Cells in the Rat Respiratory Tract
88
Respiratory Epithelial Injury and Repair
155
Inhaled Diesel Exhaust Induces DNA Adducts in the Rat Respiratory Tract
172
Cell Specificity for DNA Methylation and Repair in Rat Lung Following Exposure to Nitrosamines
182
Carcinogenesis of Respiratory Epithelium
193
Mechanisms of Neuroendocrine Lung Carcinogenesis
195
Changes in Cellular Responses to Inducers of Differentiation Growth Factors and Oncogenes During Neoplastic Progression of Respiratory Epithelial ...
205
Growth Differentiation and Transformation Studies of Human Bronchial Epithelial Cells
217
Autocrine Growth Factors That Regulate the Proliferation of Pulmonary Malignancies in Man
228

The Role of Clara Cells and Basal Cells as Epithelial Stem Cells of the Conducting Airways
99
In Vitro Studies of Human Mesothelioma
112
Toxicology of Respiratory Epithelium
125
Responses of Type II Pneumocytes to Oxidant Stress
129
Involvement of Active Oxygen Species AOS in Injury Repair and Proliferation of Tracheobronchial Epithelial Cells After Exposure to Asbestos Fibers
145
Activated Oncogenes in Rodent and Human Lung Tumors
271
Dominant and Recessive Oncogenes in the Pathogenesis of Lung Cancer
288
Index
306
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