Biology and Physiology of the Blood-Brain Barrier: Transport, Cellular Interactions, and Brain Pathologies
Pierre-Olivier Couraud, Daniel Scherman
Springer US, Dec 31, 1996 - Medical - 388 pages
The endothelial cells of the cerebral vasculature constitute, together with perivascular elements (astrocytes, pcricytes, basement membrane), the blood-brain barrier (BBB), which strictly limits and specifically controls the exchanges between the blood and the cerebral extracellular spacc.The existence of such a physical, enzymatic, and active barrier isolating the central nervous system has broad physiological, biological, pharmacological, and patho logical consequences, most of which are not yet fully elucidated. The Cerebral Vascular Biology conference (CVB '95) was organized and held at the "Carre des Sciences" in Paris on July I 0-12, 1995. Like the CVB '92 conference held in Duluth, Minnesota, three years ago, the objectives were to provide a forum for presentation of the most recent progresses and to stimulate discussions in the ticld of the biology, physiology. and pathology of the blood-brain barrier. The Paris conference gathered more than !50 participants. including investigators in basic neuroscience, physicians. and stu dents, who actively contributed to the scientific program by their oral or poster presentations. This volume contains a collection of short articles that summarize most of the new data that were presented at the conference. Six thematic parts focus on physiological transports. drug delivery, multidrug resistance P-glycoprotein, signal transduction at the BBB. interactions between the immune system and the cerebral endothelial cells, and the blood-brain barrier-related pathologies in the central nervous system. In addition, two introductory articles present new insights in the rapidly evolving topics of cerebral angiogenesis and gene transfer to the brain.
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activity adhesion albumin amino acids animals antibody apical astrocytes BBB permeability BCEC binding Biol Biology and Physiology blood-brain barrier blood-brain barrier BBB blood-retinal barrier brain capillary endothelial brain endothelial cells brain microvessels Brain Res capillary capillary endothelial cells cell line cellular cellules endothéliales cerebral endothelial cells cérébrale choroid plexus concentration cortex Couraud and Scherman cyclosporin cytokines dexamethasone drug edited by Couraud effect efflux endothelial cells endothelium enzyme epithelial cells experimental expression extracellular Figure function glycosylated heat stress histamine hypoxia increase incubated induced inhibition injection ketanserin kinase L-alanine lymphocyte macrophages MARCKS protein medium membrane mg/kg migration molecules monocytes monolayers nd nd Neurochem neurons nicotine observed P-glycoprotein P-gp peptide perfusion Pharmacol plasma PMNL primary cultures protein rat brain RCEC retinal Scherman Plenum Press SDZ PSC 833 serotonin serum taurine tiazofurin tight junctions tissue transport tumor uptake vascular vessels vitro vivo