Biology of Sleep Substances

Front Cover
CRC Press, Mar 31, 1989 - Science - 216 pages
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All aspects of sleep sciences are included in this excellent resource text, with special reference to sleep substances and sleep modulators. The historical development of the theories of sleep are reviewed in conjunction with the technical problems. All candidate substances are overviewed as to their sites of presence, chemical nature, bioassay techniques, physiological and pharmacological effects. On the basis of a standardized methodology developed by the author, sleep-modulatory characteristics of some substances are compared and evaluated in quantitative terms. The sleep regulatory mechanisms, which are composed of complex neurohumoral subsystems, are analyzed from the results of recent neurophysiological and neuroendocrinological experiments. Furthermore, an evolutionary aspect of sleep substances is taken into consideration.
Chapters Highlight:
Techniques for isolation and evaluation
Prostaglandins
Paradoxical sleep factors
Sleep-promoting substances and nucleosides
 

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Contents

Chapter
1
Pioneering Approaches with Modern Techniques
8
References
18
Chapter 2
25
Bioassay Procedures
32
DeltaSleepInducing Peptide and Its Derivatives
45
ExtraSleep Effects
59
Chapter 4
71
Immune Theory of SlowWave Sleep
107
SleepEnhancing Activity of PGD2
114
Suppression of Sleep by Prostaglandin Synthesis Inhibitors
121
Reciprocal Roles of PGD2 and PGE2 in Sleep Regulation
127
B Unidentified PS Factors
133
Chapter 8
143
ArousalEnhancing Substances
157
Chapter 9
165

ExtraSleep Activities of Uridine
79
Related Nucleosides
83
Interactions of Uridine with Other Substances
89
Muramyl Peptides and Immunoreactive Substances
95
Somnogenic Activity of Other Pyrogens and Immunostimulants
101
Interactions with Preexisting Sleep Substances
173
Chapter 10
179
Linkage Between Sleep Substances and TimeKeeping Mechanisms
184
Index
191
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