Biomarkers for Antioxidant Defense and Oxidative Damage

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John Wiley & Sons, Jun 9, 2011 - Medical - 380 pages
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Biomarkers for Antioxidant Defense and Oxidative Damage: Principles and Practical Applications critically evaluates the basic concepts and methodologies of conventional biomarkers as well as current state-of-the-art assays for measuring antioxidant activity/oxidative stress and their practical applications. . Biomarkers for Antioxidant Defense and Oxidative Damage: Principles and Practical Applications will be of a great interest to scientists who are involved in basic research on oxidation, applied scientists evaluating the effects of nutraceuticals or pharmaceutical compounds on antioxidant activity/oxidative stress, and physicians who want to understand the degree of oxidative damage in patients with certain chronic diseases.

Discovering sensitive and specific biomarkers for systemic oxidative damage is essential to understand the role of oxidative stress in human disease. Once these roles are clearly understood, we are able to identify novel drug and nutraceutical targets. This volume goes beyond conventional analytical methods of measuring overall antioxidant activity and provides insight to the discovery of biomarkers that reveal information on specific areas of oxidative stress. Contributed by an international list of experts, Biomarkers for Antioxidant Defense and Oxidative Damage: Principles and Practical Applications describes both conventional biomarkers and recent developments in this area.

Special Features:

  • Discusses conventional biomarkers as well as recent advances for measuring antioxidants and oxidative stress
  • Biomarkers for lipid peroxidation: isoprostane, hydroxyloctadecaenoic acid, oxysterols, and reactive carbonyl species from lipid peroxidation
  • Biomarkers for protein oxidation: carbonylation, tyrosine oxidation, ubiquitin-conjugation
  • Biomarkers for DNA oxidative damage: comet assay, hydroxylated nucleotides, and exocylcic DNA adducts
  • Recently developed biomarkers from cutting-edge technology

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The above two reviews are ADDS for weight loss are inappropriate and need to be removed . The book is a scientific masterpiece related to oxidative damage and its relation to causing chronic diseases with insite to potential reversal of these diseases. It is not intended for weight loss programs.


Preface Contributors
Enzymatic Antioxidant Defenses
Antioxidants as Biomarkers of Oxidative Stress
LDL Oxidation as a Biomarker of Antioxidant Status
Chapter 5
Hydroxyoctadecadienoic Acid HODE as a Marker
Mass Spectrometric Strategies for Identification
Quantitative Analysis Mapping
A Sensitive Marker of Oxidative
Covalent Modifications of Albumin Cys34 as
Protein Sglutathionylation and Scysteinylation
DNA Oxidation Antioxidant Effects and DNA Repair

Potential Biomarkers of Oxidative Stress
Lipid Peroxidation Originating αβunsaturated
An Overview
Measurement and Utility
Exocyclic DNA Adducts as Biomarkers of Antioxidant

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About the author (2011)

Giancarlo Aldini, Ph.D., Department of Pharmaceutical

Sciences "Pietro Pratesi", UniversitÓ degli Studi di Milano, Milan, Italy

Kyung-Jin Yeum, Ph.D., Jean Mayer USDA-Human Nutrition Research Center on Aging, Tufts University, Boston, MA, USA.

Etsuo Niki, Ph.D., , Health Research Institute, National Institute of Advanced Industrial Science & Technology, Osaka, Japan.

Robert M. Russell, M.D., Office of Dietary Supplements, National Institutes of Health, 6100 Executive Blvd., Bethesda, MD 20892-7517, USA

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