Biomaterials in Modern Medicine: The Groningen Perspective
This useful book is written from a medical perspective and is aimed at academics as well as medical and biomedical engineering students who want to become involved in the design, development, manufacturing or use of prostheses or medical devices. It covers basic information on the complexities of implant and medical device development. The design process, technology assessment, animal experiments, histocompatibility, tissue compatibility and infections are described. In addition, examples of biomaterial applications are presented, showing the diversity of biomaterials.This is the first book that guides the reader through the complicated process of medical product development. Different technical and medical aspects of medical implants are highlighted by a group of authors who are actively involved in biomaterial research at the University Medical Center of Groningen, one of the leading hospitals in The Netherlands.
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Chapter 1 Introduction JPA Nicolai and G Rakhorst
Chapter 2 Design of Biomedical Products GJ Verkerke and EB van der Houwen
Chapter 3 Animal Models in Biomaterials Research G Rakhorst EJO ten Hallers and CMA Thuring
Chapter 4 Technology Assessment JM Hummel
Chapter 5 Haemocompatibility of Medical Devices W van Oeveren
Chapter 6 Tissue and Cell Interactions with Materials TG van Kooten and R Kuijer
Chapter 7 Biomaterialassociated Surgery and Infection A Review of the Literature PGM Maathuis SK Bulstra HC van der Mei JR van Horn and HJ B...
Case 1 Cardiopulmonary Bypass and Postoperative Organ Dysfunction Y John Gu
Case 2 Mechanical Circulatory Support Systems G Rakhorst and ME Erasmus
Case 3 Biomaterialrelated Infections in Orthopedic Implants D Neut and RL Diercks
Case 4 Biomaterials for Voice Reconstruction GJ Verkerke JW Tack IF Herrmann HF Mahieu BFAM van der Laan and HK Schutte
Case 5 Biomaterials in Ophthalmology SA Koopmans and VW Renardel de Lavalette
Case 6 Biomaterials in Plastic Surgery MF Meek
Case 7 Surgical Meshes Morphologydependent Bacterial Colonization AF Engelsman
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abdominal wall activation adhesion animal models antibiotic application bacterial biocompatibility biofilm biofilm formation biomaterial biomaterial-associated BioMedical Engineering blood pumps body bone cement Bone Joint Surg capsule cardiac cardiopulmonary bypass catheter cells chronic Clin Orthop clinical coating collagen complications coronary artery Department of BioMedical effects extracorporeal fibronectin function gentamicin Groningen The Netherlands haemocompatibility heart failure heart valve heart-lung machine hyaluronic acid hydrophilic hydrophobic IABP implant increased infection rates inflammation interactions intraocular lens intraocular lenses laryngectomy lens leukocytes lung material surface mechanical Medical Center Groningen medical devices membrane ment metal micro-organisms multifilament organ oxygen patients phase PhD Department plasma platelet PMMA polymer post-operative problem prosthesis proteins PUCA pump Rakhorst retinal retinal detachment SBIs shunt valve stents studies surgeons surgical meshes techniques tion total hip arthroplasty tracheostoma treatment University Medical Center ventricular assist device Verkerke GJ vitreous vitro voice prostheses wettability wound