Biomaterials as Stem Cell Niche

Front Cover
Krishnendu Roy
Springer Science & Business Media, Sep 30, 2010 - Technology & Engineering - 309 pages
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Recent developments in stem cell biology have opened new directions in cell therapy. This book provides the state-of-the-art developments in using biomaterials as artificial niches for engineering stem cells, both for the purpose of better understanding their biology under 3D biomimetic conditions as well as for developing new strategies for efficient long term maintenance and directed differentiation of stem cells into various therapeutic lineages. Animal and human stem cells of both embryonic and adult origin are discussed with applications ranging from nerve regeneration, orthopedics, cardiovascular therapy, blood cell generation and cancer therapy. Both synthetic and natural biomaterials are reviewed with emphasis on how material-stem cell interactions direct specific signaling pathways and ultimately modulate the cell fate. This book is valuable for biomaterial scientists, tissue engineers, clinicians as well as stem cell biologists involved in basic research and applications of adult and embryonic stem cells.

 

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Contents

Engineering ECM Complexity into Biomaterials for Directing Cell Fate
1
Functional Biomaterials for Controlling Stem Cell Differentiation
19
Integration of Biomaterials into 3D Stem Cell Microenvironments
45
Stem Cell Interaction with Topography
61
The Nanofiber Matrix as an Artificial Stem Cell Niche
88
Micropatterned Hydrogels for Stem Cell Culture
119
Microengineering Approach for Directing Embryonic Stem Cell Differentiation
153
Biomaterials as Stem Cell Niche Cardiovascular Stem Cells
173
The Integrated Role of Biomaterials and Stem Cells in Vascular Regeneration
194
Synthetic Niches for Stem Cell Differentiation into T cells
225
Understanding Hypoxic Environments Biomaterials Approaches to Neural Stabilization and Regeneration after Ischemia
246
Biomaterial Applications in the Adult Skeletal Muscle Satellite Cell Niche Deliberate Control of Muscle Stem Cells and Muscle Regeneration in the Ag...
275
Author Index
309
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