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THE TISSUE ENGINEERING APPROACH TO LIGAMENT
DEVELOPMENT OF A COLLAGENGAG COPOLYMER IMPLANT
AN APPLICATION IN KNEE
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1994 Materials Research acid activity alginate alkaline phosphatase aqueous autoclaving behavior bFGF bioactive biodegradable Biomaterials bonding bone bovine buffer carboxylated cell adhesion cell attachment cell culture cell growth cellular Chemical coating collagen collagen fibers collagen scaffolds composition concentration controlled release copolymer crosslinking degradation density determined devices diameter diffusion drug effect encapsulated endothelial cell erosion fibroblasts fibronectin Figure films foams function glass glutaraldehyde grafted GRGDSY groups heparin hepatocytes hydrogels immobilized implant increased initial integrin interactions layer Materials Research Society matrix membrane microspheres molecular weight monomer morphology nutrients osteoblasts osteonectin oxide oxygen p(FAD:SA peaks peptide permeability phase PLGA PLLA polyanhydride polymer polymeric polypyrrole polyurethanes pore porous Proc properties protein receptors regeneration release rate resorbable samples serum showed solution solvent spectra stabilization structure studies substrates surface swelling ratio Symp synthesis temperature tissue culture transferrin transplantation trypsin tube Vacanti vitro