Biomechanics and Mechanobiology of Aneurysms

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Tim McGloughlin
Springer Science & Business Media, Sep 15, 2011 - Technology & Engineering - 426 pages
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Cardiovascular disease is the leading cause of morbidity and premature death of modern era medicine. It is estimated that approximately 81 million people in the United States (US) currently have one or more of the many forms of cardiovascular disease, resulting in 1 in every 2.8 deaths, or 900,000 deaths per year. 40% of all deaths in Europe are a result of cardiovascular disease in people under the age of 75. Aneurysms form a significant portion of these cardiovascular related deaths and are defined as a permanent and irreversible localised dilation of a blood vessel greater than 50% of its normal diameter. Although aneurysms can form in any blood vessel, the more lethal aneurysms develop in the cranial arteries, and in the thoracic aorta and abdominal aorta. Frequently aneurysms are undetected and if left untreated may eventually expand until rupture with very high levels of morbidity and mortality. The biomechanics and mechanobiology of aneursymal diseases are not fully understood and this monograph aims to provide new insights into aneurysm aetiology and behavior based on the most recent biomechanics research related to this important topic. The contributors to this volume bring together a unique blend of expertise in experimental, computational and tissue biomechanics relating to aneurysm behavior and enable the reader to gain a fresh understanding of the key factors influencing aneurysm behavior and treatment. Biological risk factors such as tobacco smoking, sex, age, hypertension, family history and mechanobiological risk factors such as aneurysm geometry and shape as well as mechanical properties of the diseased tissues are considered in detail as are many of the diagnostic and treatment options.

 

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Contents

Epidemiology Aetiology and Pathophysiology
1
64 Imaging of Aneurysms
34
84 Biomechanics and Pathobiology of Aortic Aneurysms
67
70 ComputerAided Diagnosis of Abdominal Aortic Aneurysms
119
71 Mechanical Properties of AAA Tissue
139
85 FluidStructure Interaction in Healthy Diseased and Endovascularly Treated Abdominal Aortic Aneurysms
163
Fluid Structure Interaction FSI Studies
180
73 Computational Analysis of Displacement Forces Acting on Endografts Used to Treat Aortic Aneurysms
221
74 Experimental Analysis of Endovascular Treatment of AAA and Predictors of Long Term Outcomes
247
75 Thoracic Aortic AneurysmsClinical Assessment and Treatment
285
Clinical Assessment and Treatment Options
331
77 Modelling Cerebral Aneurysm Evolution
373
76 Biomechanical Considerations of Animal Models of Aortic Aneurysm
400
Author Index
422
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