Biomedical Devices and Their Applications

Front Cover
D. Shi
Springer Science & Business Media, Oct 5, 2004 - Medical - 201 pages
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Biomedical devices that contact with blood or tissue represent a wide range of products. Depending on their potential harm to a body, medical devices are categorized according to the degree, so their safety can be assured. All biomaterials are by definition designed to contact with a body for a certain period of time. The nature of the body contact, as well as the duration a material contacts with the body may initiate unwanted biological In comparison with invasive devices Oike catheters and medical responses. implants contact directly with tissue or with the circulating blood) non invasive devices (like wound-dressings and contact lenses contact with the skin, the sclera, and the mucosa or with open wounds) have a lesser risk of hurting a patient. When blood contacts with a foreign material, plasma proteins become absorpted to the surface within a few seconds. The reactions that follow, the so-called intrinsic pathway lead to the formation of fibrin and activation of platelets and white blood cells, result in blood clot formation.
 

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Contents

Biomaterials in Drug Delivery
1
12 Structure and Properties of Hydrogels
3
121 Equilibrium Swelling
5
122 Network Pore Size Calculation
10
13 Diffusion in Hydrogels
12
131 Macroscopic Analysis
13
132 Network Structural Effects
15
133 Experimental Determination of Diffusion Coefficients
20
35 Some Recent Applications of Protein Electrophoresis in Biomaterials Science
79
A Case Study
81
General Considerations
84
363 Analyses of Adsorbed Proteins from Several Types of Glasses Via SDSPAGE and NativePAGE
86
37 Conclusions
90
Xenoestrogens as Endocrine Disrupters
93
42 Prevalence and Biological Effects
95
422 Xenoestrogens and Wildlife Reproduction
96

14 Classifications
23
142 SwellingControlled Release Systems
25
143 Chemically Controlled Release Systems
26
144 Environmentally Responsive Systems
28
References
30
Drug Delivery Systems for Localized Treatment of Disease
33
221 DiffusionControlled Drug Delivery Devices
36
222 WaterControlled Drug Delivery Devices
39
223 Chemically Controlled Drug Delivery Devices
40
224 LipidBased Drug Delivery Systems
41
23 Drug Delivery to the Lung
42
24 Bone Infection Treatment
44
25 Cancer Treatment
48
252 Liver Cancer
49
253 Neurological Cancer
51
254 Dermatological Head and NeckSkin Cancer
52
255 Skeletal Cancer
53
256 Breast Cancer
54
26 Conclusions
55
Acknowledgement
56
Application of Protein Electrophoresis Techniques
61
32 Common Electrophoretic Systems for Separation and Characterization of Proteins
62
321 Polyacrylamide Gel Electrophoresis PAGE
63
SDS PAGE
64
323 Other Common Electrophoretic Separation Techniques
68
What You See Depends on How You Look
71
34 Variables of State with Respect to Protein Binding at a Material Surface
75
423 The Unfortunate Consequences of Human Exposure to DES
97
424 Xenoestrogens and Tumorigenesis
99
43 Mechanism of Action
100
432 Agonistic and Antagonistic Actions
103
433 Metabolism and Genotoxicity
104
An Estrogenic Compound in Unexpected Places
105
442 Binding Affinity and in Vitro Actions
107
443 Effects of BPA on Adult Animals
108
444 Developmental Effects of Xenoestrogens
112
45 Summary and Perspectives
114
Medical Devices
119
512 A Multidisciplinary Approach to Medical Product Development
120
513 Constructive Medical Technology Assessment
121
514 Concurrent Engineering
123
52 Biological Evaluation of Medical Devices
124
522 Animal Experiments
126
53 Applications
127
531 Mechanical Circulatory Support Systems
128
532 An Extendable Modular Endoprosthetic System for Bone Tumor Management in the Leg
140
533 The Groningen Temporomandibular Joint Prosthesis
145
534 Laryngeal Prosthesis
155
535 Tracheostoma Valves
171
536 Fixation of Tracheostoma Valves
177
537 VoiceProducing Prosthesis
184
References
189
Index
201
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