Biomedical EPR - Part B: Methodology, Instrumentation, and Dynamics

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Sandra S. Eaton, Gareth R. Eaton, Lawrence J. Berliner
Springer Science & Business Media, 2005 - Biochemistry - 470 pages
Biomedical EPR – Part A focuses on applications of EPR spectroscopy in the areas of free radicals, metals, medicine, and physiology. The book celebrates the 70th birthday of Prof. James S. Hyde, Medical College of Wisconsin, and his contributions to this field. Chapters are written to provide introductory material for new-comers to the field which lead into up-to-date reviews that provide perspective on the wide range of questions that can be addressed by EPR. Key Features:Free Radicals in Medicine Radicals in vivo and in Model Systems, and their Study by Spin Trapping In vivo EPR, including Oximetry and Imaging Time Domain EPR at Radio Frequencies EPR of Copper Complexes: Motion and Frequency Dependence Time Domain EPR and Electron Spin Echo Envelope Modulation About the Editors: Prof. Sandra S. Eaton is John Evans Professor in the Department of Chemistry and Biochemistry at the University of Denver. Her research interests include distance measurements in proteins, EPR of metal ions in biological systems, electron spin relaxation times, and EPR instrumentation. The Eatons co-organize an annual EPR Symposium in Denver. Prof. Gareth R. Eaton is John Evans Professor in the Department of Chemistry and Biochemistry at the University of Denver. His research interests include EPR instrumentation, distance measurements in proteins, EPR of metal ions in biological systems, and electron spin relaxation times. Dr. Lawrence J. Berliner is currently Professor and Chair of the Department of Chemistry and Biochemistry at the University of Denver after retiring from Ohio State University, where he spent a 32-year career in the area of biological magnetic resonance (EPR and NMR). He is the Series Editor for Biological Magnetic Resonance, which he launched in 1979.
 

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Contents

1 MOTIVATION
3
2 BRIEF HISTORY
4
RECOVERY CURVES
5
5 APPLICATIONS
10
6 PROGNOSIS
15
1 INTRODUCTION
19
2 HISTORY
20
RESONATORS?
22
RELAXING CENTERS
227
CENTER AND A RAPIDLY RELAXING CENTER
228
5 SOME PRACTICAL CONSIDERATIONS
229
BETWEEN TWO SLOWLY RELAXING RADICALS
230
BETWEEN A RAPIDLY RELAXING AND A SLOWLY RELAXING SPIN
232
8 PROGNOSIS
234
9 REFERENCES
235
RADICALS
239

4 BASICS
23
5 TOPOLOGIES OF LOOP GAP RESONATORS
25
6 COUPLING TO RESONATORS
29
7 DESIGN EQUATIONS
31
8 MAGNETIC FIELD MODULATION
35
9 LGR FOR TIME DOMAIN EPR
36
10 SELECTION OF THE Q OF A LGR
40
11 MEASURING B IN THE LGR
42
12 VARIABLE TEMPERATURE
44
14 COMMERCIAL RESONATORS
45
16 FURTHER INFORMATION
47
1 INTRODUCTION
53
STOPPEDFLOW SYSTEM
55
FLOW EPR
62
FLOW EPR TO NATURALLY OCCURRING TRANSIENT RADICALS
79
APPLICATIONS OF FLOW AND STOPPED FLOW EPR
83
6 REFERENCES
84
1 INTRODUCTION
89
STRUCTURE AND CONFORMATION WITH VO2+ AND NITROXYL SPINLABELS
93
STRUCTURED SOLVENT IN SMALL MOLECULE COMPLEXES AND IN PROTEINS
102
REMARKS
132
5 REFERENCES
135
1 SOLUTIONENDOR SPECTROSCOPY
145
2 QUINONES
152
3 PORPHYRINOIDS
157
4 REFERENCES
162
1 INTRODUCTION
165
2 INSTRUMENTAL TECHNIQUES
171
CRYSTALS GLASSY SOLIDS POLYMERS AND CRYSTALS
180
4 PRACTICAL ASPECTS OF MEASUREMENTS
186
5 REFERENCES
187
Digital Detection by TimeLocked Sampling in EPR
199
DETECTION EPR INSTRUMENTDESIGN BACKGROUND
203
FOR CW EPR
204
LOCKED SUBSAMPLING
209
5 SELECTED ENGINEERING CONSIDERATIONS
212
6 CONCLUSION
220
7 REFERENCES
221
1 INTRODUCTION
223
INTERACTION BETWEEN ELECTRON SPINS
224
DYNAMICS
241
DYNAMICS
242
DYNAMICS
246
5 SPINECHOES AND MOLECULAR DYNAMICS
251
ESR
256
7 PROSPECTUS
263
9 GLOSSARY OF ABBREVIATIONS
264
1 INTRODUCTION
269
2 SOLVENT ACCESSIBILITY
271
3 MOTION
280
4 DISTANCE MEASUREMENTS
290
5 METHODOLOGY
298
6 CONCLUSION
300
1 INTRODUCTION
309
2 HISTORICAL DEVELOPMENT
311
EPR DISPLAYS
313
4 MODULATIONCOUPLED BLOCK EQUATIONS
315
5 SLOW ROTATIONAL DIFFUSION
320
SLOW ROTATION
324
7 JISENSITIVE NONLINEAR EPR DISPLAYS
331
ENHANCEMENTS
339
RELAXATION ENHANCEMENTS
348
10 OUTLOOK
358
11 REFERENCES
363
1 INTRODUCTION
369
2 METHODS FOR ANALYSIS OF STEPR DATA
373
OF STEPR SPECTRA
376
DATA ANALYSIS
382
5 MODEL CALCULATIONS OF STEPR SPECTRA USING THE TRANSITION RATE MATRIX APPROACH
383
PROTEINS
396
7 REFERENCES
401
1 INTRODUCTION
409
2 RESONATORS
410
3 NOISE
415
4 MULTIFREQUENCY EPR
420
5 EPR FOR ROUTINE ANALYSIS
423
6 DISCUSSION
425
7 REFERENCES
426
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