Biopharmaceutical Sequential Statistical Applications

Front Cover
Karl E. Peace
CRC Press, Mar 25, 1992 - Mathematics - 376 pages
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Focusing on group sequential procedures, summarizes the sequential statistical methods used in anticancer, antiviral, cardiovascular, and gastrointestinal drug research and screening. The clinical and preclinical applications are mainly presented as case studies, many of which form part of New Drug
 

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Contents

Overview of the Development of Sequential Procedures
3
Discussion
11
Practical Approaches to the Design and Conduct of Interim
19
Group Sequential Designs for Trials with Multiple
29
Applications in Drug Screening
37
Stagewise Group Sequential Experimental Designs
87
Application of a Sequential ScreeningEfficacy Design in
119
Discussion
141
Interim Analysis of the Helsinki Heart Study Primary
235
Plans for the Enalapril PostMITrial CONSENSUS
245
16
255
Famotidine in Upper Gastrointestinal Hemorrhage
271
Statistical Analyses
277
Sample Size Reestimation in Clinical Trials
285
114
289
Conclusion
313

Group Sequential Trial of Two Combination Chemotherapy Regimens
155
Early Termination of a Trial of Azidothymidine for the Treatment
165
10
175
An Application of the Sequential Probability Ratio Test to an Unblinded
189
12
201
105
217
Interim Analysis in the Norwegian Multicenter Study
219
Discussion
314
219
324
A Sequential Trial of Dantrolene in Human Malignant
325
Randomized PlaytheWinner Designs and ECMO
333
119
345
31
347
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