Biophysical Regulation of Vascular Differentiation and Assembly

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Sharon Gerecht
Springer Science & Business Media, Jan 6, 2011 - Science - 254 pages
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Because of their ability to differentiate and develop into functional vasculature, stem cells hold tremendous promise for therapeutic applications. However, the scientific understanding and the ability to engineer these cellular systems is still in its early stages, and must advance significantly for the therapeutic potential of stem cells to be realized. Stem cell differentiation and function are exquisitely tuned by their microenvironment. This book will provide a unique perspective of how different aspect of the vasculature microenvironment regulates differentiation and assembly. Recent efforts to exploits modern engineering techniques to study and manipulate various biophysical cues will be described including: oxygen tension during adult and embryonic vasculogenesis (Semenza and Zandstra), extracellular matrix during tube morphogenesis and angiogenesis (Wirtz, Davis, Ingber), surface topography and modification (Chen and Gerecht), shear stress and cyclic strain effect on vascular assembly and maturation (Vunjak-Novakovic and Niklason), and three dimensional space for angio-andvasculogensis (Ferreria and Fischbach).

 

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Contents

The Emergence of Blood and Blood Vessels in the Embryo and Its Relevance to Postnatal Biology and Disease
1
Molecular Control of Vascular Tube Morphogenesis and Stabilization Regulation by Extracellular Matrix Matrix Metalloproteinases and Endothelial ...
17
Scaffolding for ThreeDimensional Embryonic Vasculogenesis
49
Intra and Extracellular Microrheology of Endothelial Cells in a 3D Matrix
68
Biophysical Properties of Scaffolds Modulate Human Blood Vessel Formation from Circulating Endothelial ColonyForming Cells
89
Physiological and Therapeutic Vascular Remodeling Mediated by HypoxiaInducible Factor 1
110
Hypoxia and Matrix Manipulation for Vascular Engineering
127
Microenvironmental Regulation of Tumor Angiogenesis Biological and Engineering Considerations
166
Microbioreactors for Stem Cell Research
203
Effects of Hemodynamic Forces on the Vascular Differentiation of Stem Cells Implications for Vascular Graft Engineering
227
Index
245
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