Biophysics

Front Cover
Springer Science & Business Media, Mar 31, 2002 - Science - 253 pages

Biophysics, being an interdisciplinary topic, is of great importance in modern biology. This book addresses the needs of biologists, biochemists, and medical biophysicists for an introduction to the subject. The text is based on a one-semester course offered to graduate students of life sciences, and covers a wide range of topics from quantum mechanics to pre-biotic evolution. To understand the topics, only basic school level mathematics is required.

The first chapter introduces and refreshes the reader's knowledge of physics and chemistry. The next chapters cover various physico-chemical techniques used to study biomolecular structures, followed by treatments of spectroscopy, microscopy, diffraction, and computational techniques.

X-ray crystallography and NMR are dealt with in greater detail. The latter half of the book covers results obtained from applications of the above techniques. Some of the other topics dealt with are energy pathways, biomechanics, and neuro-biophysics.

 

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Contents

13 The Electronic Structure of Atoms
3
14 Molecular Orbitals and Covalent Bonds
5
15 Molecular Interactions
8
16 Stereochemistry and Chirality
11
17 Thermodynamics
13
18 Radioactivity
20
2 Separation Techniques
24
23 Electrophoresis
32
78 Structure Solution
106
79 Refinement of the Structure
108
710 Note on the Resolution of an Xray Structure
111
NMR Spectroscopy
112
83 NMR Theory and Experiment
114
84 Classical Description of NMR
115
85 NMR Parameters
117
86 The Nuclear Overhauser Effect
122

3 PhysicoChemical Techniques to Study Biomolecules
37
32 Hydration of Macromolecules
38
34 Diffusion
39
35 Sedimentation
41
36 The Ultracentrifuge
43
37 Viscosity
46
38 Rotational Diffusion
48
39 Light Scattering
51
310 Small Angle Xray Scattering
54
4 Spectroscopy
58
42 UltravioletVisible Spectroscopy
59
44 Fluorescence Spectroscopy
65
45 Infrared Spectroscopy
67
46 Raman Spectroscopy
71
47 Electron Spin Resonance
74
5 Light Microscopy
77
53 The Limits of Resolution
79
54 Different Types of Microscopy
82
6 Electron Microscopy
86
65 Preparation of the Specimen for Electron Microscopy
90
66 Image Reconstruction
91
67 Electron Diffraction
92
69 Atomic Force Microscope
93
7 Xray Crystallography
95
73 Crystal Systems
96
74 Point Groups and Space Groups
97
75 Growth of Crystals of Biological Molecules
99
76 Xray Diffraction
103
77 Xray Data Collection
105
88 NMR Application in Biochemistry and Biophysics
124
89 NMR in Medicine
128
9 Molecular Modelling
131
93 Optimising the Model
138
10 Macromolecular Structure
144
103 Protein Structure
161
11 Energy Pathways in Biology
174
113 Coupled Reactions
176
114 Group Transfer Potential
177
115 Role of Pyridine Nucleotides
178
116 Photosynthesis
179
117 Energy Conversion Pathways
187
118 Membrane Transport
194
12 Biomechanics
199
123 Mechanical Properties of Muscles
202
124 Biomechanics of the Cardiovascular System
205
13 Neurobiophysics
210
133 Physics of Membrane Potentials
213
134 Sensory MechanismsThe Eye
217
135 Physical Aspects of Hearing
227
136 Signal Transduction
230
14 Origin and Evolution of Life
232
142 Prebiotic Earth
233
143 Theories of Origin and Evolution of Life
234
144 Laboratory Experiments on the Formation of Small Molecules
235
FURTHER READING
243
INDEX
247
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