Bioradicals Detected by Esr Spectroscopy

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Hiroaki Ohya-Nishiguchi, Lester Packer
Springer Science & Business Media, Nov 29, 1995 - Science - 337 pages
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This book is based on two keywords: Bioradical and ESR. Bioradical is a newly coined word which encompasses paramagnetic species in biological systems, such as active oxygen radicals and transition metal ions. Research on the structure and function of bioradicals has been attrac ting growing attention in the field of biological science, and comprehensive investigations from many fields are helping to understand the real features of these species. ESR spectroscopy also has interdisciplinary features in that its techniques have been applied to many fields, ranging from physics to medicine. It was our hope, therefore, that this book would help to clarify many aspects of bioradicals and that significant progress would be achieved in combining basic research from many different fields. This book arises from the First International Conference on Bioradicals Detected by ESR Spectroscopy (ICBES), which was held in Yamagata, a city in the Yamagata Prefecture of Japan, in 1994. About 300 participants from 16 different countries attended this conference, and about 170 papers were presented. This book is a collection of contributions from the conference and also contains eleven chapters selected by the editorial board, based on sugges tions from the members of the international editorial board of ICBES. The Yamagata Technopolis Foundation is developing a biomedical technology for the 21st century based on life science fused with material and physical science. Based on such a techno logy, the Foundation plans to share its fruits all over the world.

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Overview of bioradicals and ESR technology
Chemistry of oxygen radicals
Physics technology and applications to bioradicals
Scanning tunneling microscopy STM methods for detecting ESR of a single spin center
An open space ESR spectrometer and its application to high dielectric loss samples
New experimental modalities of low frequency electron paramagnetic resonance imaging
Whole body electron spin resonance imaging spectrometer
Development of the rapid field scan Lband ESRCT system
Recent developments in spin labeling
Electron spin resonance imaging of rat brain
ESEEM spectroscopy probing active site structures of metalloproteins
Nitric oxide a versatile biological ligand for hemeproteins
Vitamin E and antioxidant interactions in biological systems
Antioxidant activity of vitamin E and vitamin C derivatives in membrane mimetic systems
Action of antioxidants as studied by electron spin resonance
In vivo EPR spectroscopy

Spin trapping
History of spin trapping in Japan
In vivo ESR observation of bioradical metabolites in living animals
Dithiocarbamate spin traps for in vivo detection of nitric oxide production in mice
Pharmaceutical aspects of ESR investigations on drug delivery systems tissues and living systems
In vivo ESR measurement of free radical reactions in living animals using nitroxyl probes
Subject index

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About the author (1995)

Packer is regarded as the world's foremost antioxidant research scientist. Head of the Packer Lab at the University of California at Berkeley. He is the senior scientist at the prestigious Lawrence Berkeley Laboratory.

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