Biosignal transduction mechanisms
This book presents current results obtained from research activities on biosignal transduction. The mechanism of how an external signal is processed inside the cell or cell membrane is treated, mainly the transmission by ion channels via the regulation of ion currents and the involved second messengers such as G-proteins and inositolphosphates. Following a theoretical approach the latest techniques for the investigation of receptor-coupled ion channels such as microinjection of m-RNA molecules into oocytes or immunological methods are described. A chapter on transduction mechanisms in chemoreception completes this volume.
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biophysical aspects of the transmembrane signaling
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Acad activation affinity agonist Akaike amino acid amino acid sequences antagonist Ba2+ bicuculline Biol Biophys brain C-kinase Ca2+ calcium channels cDNA cGMP Chem Colquhoun depolarization desensitization diacylglycerol digitonin effect of ACh entropy equilibrium fast components function G-proteins GABA GABA concentration GVIA Haga Hirono hyperpolarization induced injection interaction intracellular ION CHANNEL DYNAMICS ion channels ionic K+ channels Kijima and Kijima kinetics Koketsu Kuba Kurihara ligand ligand binding M-channel mAChR MD-type cells membrane potential molecular molecules mRNA msec MUSCARINIC REGULATION MWC model Natl neurons Neurosci obtained odorants olfactory oocytes patch period Pharmacol phospholipid phosphorylation Physiol PIP2 pirenzepine Proc protein kinase rate constants reaction model record REGULATION OF ION response rhodopsin Sakmann second messenger serotonin shown shut slow components solution state-transition model steady-state steady/equilibrium approximation subtypes subunits Sugiyama tion transduction mechanism transition Tsuji voltage voltage-dependent