Biosimulation in Biomedical Research, Health Care and Drug Development

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Erik Mosekilde, Olga Sosnovtseva, Amin Rostami-Hodjegan
Springer Science & Business Media, Nov 1, 2011 - Medical - 396 pages
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Biosimulation is an approach to biomedical research and the treatment of patients in which computer modeling goes hand in hand with experimental and clinical work. Constructed models are used to interpret experimental results and to accumulate information from experiment to experiment.

This book explains the concepts used in the modeling of biological phenomena and goes on to present a series of well-documented models of the regulation of various genetic, cellular and physiological processes. The way how the use of computer models allows optimization of cancer treatment for individual patients is discussed and models of interacting nerve cells that can be used to design new treatments for patients with Parkinson's disease are explained. Furthermore this volume provides an overview on the use of models in industry, and presents the view of regulatory agencies on the topic.


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Chapter 1 Modeling in Biomedical Research and Health Care
Chapter 2 Concepts in Mechanism Based Modeling
Chapter 3 The Approach to Model Building
Chapter 4 Emergence of Oscillatory Dynamics
Chapter 5 ConductanceBased Models for the Evaluation of Brain Functions Disorders and Drug Effects
Chapter 6 Functional Modeling of NeuralGlial Interaction
Chapter 7 ActivityRelated Structural Changes in the Myelinated Nerve Fiber
Chapter 8 ClosedLoop Control of Brain Rhythms
Chapter 10 Synchronization of Cellular Contractions in the Arteriolar Wall
Chapter 11 Microvascular Plasticity
Chapter 12 Bifurcations and Multistability in Periodically Stimulated Cardiac Cells
A Case in Biological Studies
Chapter 14 MultilevelModeling Core Predictions and the Concept of Final Conclusions
Chapter 15 Absorption Kinetics of Insulin Mixtures after Subcutaneous Administration
Chapter 16 PhysiologicallyBased Pharmacokinetics

Chapter 9 Modeling Ca2+ Microdomains

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About the author (2011)

Erik Mosekilde was born in Århus, Denmark on May 26, 1941. In March 1966 he graduated (summa cum laude) from The Technical University of Denmark as an electrical engineer specialized in solid state physics, and in September 1968 he completed his Ph.D. studies at Physics Laboratory III with a thesis on acoustoelectric effects in piezoelectric semiconductors. Having performed his military service Erik Mosekilde was offered a postdoctoral position at Physics Laboratory III and shortly after received a postdoctoral fellowship from IBM, which allowed him to spend 9 months at Thomas J. Watson Research Center, Yorktown Heights, New York. In July 1972 Erik Mosekilde was appointed associate professor in modern physics, and in August 1977 he defended a dissertation on "Linear and Nonlinear Acoustoelectric Effects in Heavily Doped GaAs Epitaxial Single Crystals" for the Danish Doctor's degree at The University of Copenhagen. In September 2000 he was appointed Professor in Biological Applications of Nonlinear Dynamics at The Technical University of Denmark. Erik Mosekilde has been a member of various educational boards (1977-1982) and for six years (1982-1988) he was a member of Konsistorium, the governing body of The Technical University of Denmark. He has also served and as Vice President and member of the Policy Council for The System Dynamics Society (1984-1993), as member of the steering committee and chairman of the Scandinavian Simulation Society (1986-1992), as member of the Academic Advisory Group for the ERASMUS programme (1988-1990), as member of the J.W. Forrester Award Committee (1987-1997), as statistical consultant in medicine (1986-1998), as member of the steering committee for the Center for Chaos and Turbulence Studies, CATS (1992-2002), as chairman for the Center for Modeling, Nonlinear Dynamics and Irreversible Thermodynamics (1992-2006), as member of the steering committee for an EU COST-program on nonlinear dynamics in mechanical processing (1997-2001), as member of the steering committee for the Danish Graduate School in Nonlinear Science (1997-2002), as member of the steering committee for an INTAS program on coupled biological oscillators (2002-2005), as head of the Department of Physics (1996-2005), and as evaluator for a variety of national and international science foundations.

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