Biostatistical Genetics and Genetic Epidemiology

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Robert C. Elston, Jane M. Olson, Lyle Palmer
John Wiley & Sons, Apr 22, 2002 - Mathematics - 831 pages
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Human Genetics concerns the study of genetic forces in man. By studying our genetic make-up we are able to understand more about our heritage and evolution. Some of the original, and most significant research in genetics centred around the study of the genetics of complex diseases - genetic epidemiology.

This is the third in a highly successful series of books based on articles from the Encyclopedia of Biostatistics. This volume will be a timely and comprehensive reference, for a subject that has seen a recent explosion of interest following the completion of the first draft of the Human Genome Mapping Project. The editors have updated the articles from the Human Genetics section of the EoB, have adpated other articles to give them a genetic feel, and have included a number of newly commissioned articles to ensure the work is comprehensive and provides a self-contained reference.
 

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Contents

Akaikes Criteria
17
Association
28
Assortative Mating
34
Bayes Theorem
51
Biointormatics
61
Blood Groups
69
Bootstrap Method
75
Candidate Gene
83
GenomeWide Significance
344
Haplotype Analysis
361
Hidden Markov Models
374
Human Genome Project
390
Incidence Rate
406
KinCohort Studies
419
Likelihood
435
Linkage Analysis ModelBased
448

CaseCohort
89
CaseControl Study
95
CaseOnly Gene Mapping
109
Cohort Studies
120
Collinearity
134
Complex Diseases
141
Consistent Estimator
152
Controls
158
Correlation
171
Diagnostics
191
DiseaseMarker Association
206
DNA Sequences
217
Dummy Variables
227
Eugenics
246
Expectation
253
Family History Validation
261
FamilyBased CaseControl Studies
267
Fixed Effects
275
Frequency Matching
284
Gene Frequency Estimation
293
General Linear Model
299
Generalized Linear Model
311
Generalized Maximum Likelihood
324
Genetic Counseling
331
Genetic Heterogeneity
340
Linkage Disequilibrium
472
Loss of Heterozygosity
486
Markers
501
Neural Networks
579
Parental Effects
595
Pedigrees Sequential Sampling
619
Polymorphism
632
Profile Likelihood
652
Random Effects
665
Regression
666
Relationship Testing
673
Residuals
679
Response Variable
687
Segregation Analysis Classical
693
Segregation Ratios
708
Sex Ratio at Birth
716
Skewness
725
Specificity
736
Transition Probabilities
742
Twin Concordance
756
Unbiasedness
767
Variance
777
Xlinkage
791
Zygosity Determination
797
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