# Biostatistical Methods in Epidemiology

John Wiley & Sons, Apr 11, 2003 - Medical - 408 pages
An introduction to classical biostatistical methods in epidemiology

Biostatistical Methods in Epidemiology provides an introduction to a wide range of methods used to analyze epidemiologic data, with a focus on nonregression techniques. The text includes an extensive discussion of measurement issues in epidemiology, especially confounding. Maximum likelihood, Mantel-Haenszel, and weighted least squares methods are presented for the analysis of closed cohort and case-control data. Kaplan-Meier and Poisson methods are described for the analysis of censored survival data. A justification for using odds ratio methods in case-control studies is provided. Standardization of rates is discussed and the construction of ordinary, multiple decrement and cause-deleted life tables is outlined. Sample size formulas are given for a range of epidemiologic study designs. The text ends with a brief overview of logistic and Cox regression. Other highlights include:

• Many worked examples based on actual data
• Discussion of exact methods
• Recommendations for preferred methods
• Extensive appendices and references

Biostatistical Methods in Epidemiology provides an excellent introduction to the subject for students, while also serving as a comprehensive reference for epidemiologists and other health professionals.

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### Contents

 1 Introduction 1 2 Measurement Issues in Epidemiology 31 3 Binomial Methods for Single Sample Closed Cohort Data 77 4 Odds Ratio Methods for Unstratified Closed Cohort Data 89 5 Odds Ratio Methods for Stratified Closed Cohort Data 119 6 Risk Ratio Methods for Closed Cohort Data 143 7 Risk Difference Methods for Closed Cohort Data 151 8 Survival Analysis 159
 14 Sample Size and Power 281 15 Logistic Regression and Cox Regression 295 Appendix A Odds Ratio Inequality 307 Appendix B Maximum Likelihood Theory 311 Appendix C Hypergeometric and Conditional Poisson Distributions 325 Appendix D Quadratic Equation for the Odds Ratio 329 Appendix E Matrix Identities and Inequalities 331 Appendix F Survival Analysis and Life Tables 339

 9 KaplanMeier and Actuarial Methods for Censored Survival Data 171 10 Poisson Methods for Censored Survival Data 193 11 Odds Ratio Methods for CaseControl Data 229 12 Standardized Rates and AgePeriodCohort Analysis 249 13 Life Tables 263
 Appendix G Confounding in Open Cohort and CaseControl Studies 343 Appendix H Odds Ratio Estimate in a Matched CaseControl Study 353 References 359 Index 377 Copyright

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Page 373 - University Group Diabetes Program: A study of the effects of hypoglycemic agents on vascular complications in patients with adult -onset diabetes: I. Design, methods and baseline results, Diabetes 19 (suppl. 2):747-783, 1970; II. Mortality results, Diabetes 19 (suppl. 2): 789-830, 1970. University Group Diabetes Program: Effects of hypoglycemic agents on vascular complications in patients with adult-onset diabetes.