Biotechnology, Products of Secondary Metabolism
H. Kleinkauf, Hans von Döhren
Wiley, Jul 14, 1997 - Science - 743 pages
Products of secondary metabolism from fermentation and cell culture are mainly pharmaceuticals, ranging from traditional antibacterials like beta-lactams, new generation compounds like dalbaheptides and lantibiotics to immunomodulators and antitumor drugs. The major fields of application of these low volume/high price products are human and veterinary medicine as well as plant protection. In this volume functionally based screening approaches and the applications of molecular genetics in the discovery and process improvement of compounds are emphasized. Along with the exploitation of new sources the growing understanding of biosynthetic processes permits the identification of the genetic backgrounds.
Topics included are: Novel Receptor-Active Compounds - Microbial Lipids - Microbial Siderophores - beta-Lactam Antibiotics - Peptide Antibiotics - Lantibiotics - Glycopeptide Antibiotics (Dalbaheptides) - Aminoglycosides - Products from Basidiomycetes - Cyclosporins - Secondary Products from Plant Cells - Antitumor Agents
What people are saying - Write a review
We haven't found any reviews in the usual places.
General Aspects of Secondary 10 Aminoglycosides and Sugar
Regulation of Bacterial Antibiotic W Piepersberg J Disller
2 other sections not shown
Other editions - View all
3-lactam actinomycetes acyl afsR alkaloids amino acid aminoglycosides antagonists anthracyclines anti antibacterial antibiotic production antifungal antitumor Bacillus Bacillus subtilis bacteria Bacteriol binding Biochem Biol biological activity biosyn biosynthesis biosynthetic genes Biotechnology biotic cell characterization Chem chemical chrysogenum Cloning coelicolor coli complex compounds cultures cyclophilin cyclosporin CYP-A cytotoxic derivatives Dohren domain drugs encoding enzyme epidermin factors fatty acids fermentation ferrichrome formation function fungi gene gene cluster genetic glucose glycopeptide griseus growth inhibit inhibitors involved iron isolated Jung levels lipid membrane metabolism microbial Microbiol microorganisms modified moiety molecular molecule mutants mycin nisin novel pathway penicillin Pep5 peptide phosphorylation Piepersberg plant polyketide ppGpp precursor protein kinase Ratledge reactions receptor regulation regulatory residues resistance Sahl secondary metabolites Sect sequence siderophore specific strains Streptomyces sp strobilurin structure studies substrate subtilin subtilis synthase synthesis synthetase teicoplanin tion transcription ture vancomycin Winkelmann yeast