Biotechnology: a multi-volume comprehensive treatise
Bioprocessing: an exciting new engineering discipline. It combines the development and optimization of biotechnological processes with effective strategies to recover and purify the desired products. Safety as well as cost play an important role here. This volume covers the immensely differentiated spectrum of techniques and operations of bioprocessing, presented by the most competent experts in the field. An overview of upstream and downstream processing is given, fermentation and cell culture processes and the design of microbial fermenters are presented. A closing group of chapters is dedicated to issues of process validation, measurement, and regulation. Topics included are: Industrial Cell Cultures/ Pharmaceutical Proteins/ Bioreactors/ Media and Air Sterilization/ Oxygen Transfer/ Scale Implications/ Fermentation Data Analysis/ Cell and Debris Removal/ Protein Purification/ Electrokinetic Separations/ Final Recovery Steps/ Process Validation
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Dr CarlGustaf Rosen Dr Ron Spears
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aeration agitation amino acids anaerobic animal cell antibodies application batch Biochem Bioeng biomass bioprocess bioreactor Biotechnol Biotechnology broth bubble calculated carbon dioxide cell culture cell lines Chem chemical coli concentration correlation diameter effects enzymes equation Escherichia coli estimation ethanol factor fed-batch fermentation processes fermentor filter filtration fluid gas phase gas-liquid glucose heat hybridoma impeller increase kinetics mammalian cell mass transfer coefficient measurements medium membrane ment mentation metabolic metabolites methods microbial microcar microcarriers microorganisms mixing nutrients on-line operation optimization oxygen transfer parameters particles penicillin peptides plasmid power input pressure Proc protein purification reactor recombinant scale scale-up secondary metabolites Sect serum shear sparged sparger specific growth rate sterilization stirred tank substrate surface techniques temperature tion tryptophan tubing ture uptake rate variables velocity vessel viscosity volume Wang yeast yield