Biotechnology, Products of Secondary Metabolism
H. Kleinkauf, Hans von Döhren
Wiley, Jul 14, 1997 - Science - 743 pages
Products of secondary metabolism from fermentation and cell culture are mainly pharmaceuticals, ranging from traditional antibacterials like beta-lactams, new generation compounds like dalbaheptides and lantibiotics to immunomodulators and antitumor drugs. The major fields of application of these low volume/high price products are human and veterinary medicine as well as plant protection. In this volume functionally based screening approaches and the applications of molecular genetics in the discovery and process improvement of compounds are emphasized. Along with the exploitation of new sources the growing understanding of biosynthetic processes permits the identification of the genetic backgrounds.
Topics included are: Novel Receptor-Active Compounds - Microbial Lipids - Microbial Siderophores - beta-Lactam Antibiotics - Peptide Antibiotics - Lantibiotics - Glycopeptide Antibiotics (Dalbaheptides) - Aminoglycosides - Products from Basidiomycetes - Cyclosporins - Secondary Products from Plant Cells - Antitumor Agents
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General Aspects of Secondary 10 Aminoglycosides and Sugar
H von Dohren U Grdfe Metabolites
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3-lactam alkaloids amino acid aminoglycosides Anke antagonists anti antibacterial antibiotic production antifungal antitumor Bacillus bacteria Bacteriol basidiomycetes binding Biochem Biol biological activity biosyn biosynthesis biosynthetic genes Biotechnol calcineurin cell cultures characterization Chem chemical chrysogenum cloned coelicolor coli complex compounds cyclophilin cyclosporin CYP-A cytotoxic derivatives Dohren domain drugs duction encoding enzyme factors fatty acids fermentation formation fungal fungi gene cluster genetic glycopeptide griseus growth immunosuppressive inhibit inhibitors involved isolated kinase Lett levels ligand lipid membrane metabolism microbial Microbiol microorganisms moiety molecular molecule mutants mycin nisin novel pathway penicillin peptide Piepersberg plant cell cultures plant tissue culture polyketide precursor protein Ratledge reactions receptor regulation regulatory residues rosmarinic acid Sahl screening secondary metabolites Sect sequence siderophore specific Steglich strains Streptomyces sp strobilurin structure studies substrate subtilin subtilis synthase synthesis taxol teicoplanin tion tissue culture transcription tures vancomycin yeast