Biothermodynamics, Part 1

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Michael L. Johnson, Jo M. Holt, Gary K. Ackers
Academic Press, Mar 14, 2009 - Science - 996 pages
In the past several years, there has been an explosion in the ability of biologists, molecular biologists and biochemists to collect vast amounts of data on their systems. This volume presents sophisticated methods for estimating the thermodynamic parameters of specific protein-protein, protein-DNA and small molecule interactions.

The use of thermodynamics in biological research is used as an “energy book-keeping system. While the structure and function of a molecule is important, it is equally important to know what drives the energy force. These methods look to answer: What are the sources of energy that drive the function? Which of the
pathways are of biological significance? As the base of macromolecular structures continues to expand through powerful techniques of molecular biology, such as X-ray crystal data and spectroscopy methods, the importance of tested and reliable methods for answering these questions will continue to expand as well.
 

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About the author (2009)

Born in 1928 and educated at Magdalene College, Oxford, Paul Johnson was editor of the influential English weekly, "The New Statesman, " from 1964-1970, and is now Director, New Statesman Publishing Company. Mr. Johnson's prodigious scholarship and varied interests are evident in the themes of his books. Since publication of "A History of Christianity" he has written "Enemies of Society, The Civilization of Ancient Egypt" and "Civilizations of the Holy Land.

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