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1H NMR activity agent Key functional alcohol Alkyl aryl aryl amine Arylalkyl bile biotransformation pathway cannabidiol carboxylic acid carcinogen CH2OH chiral chromatographic compound Key compound Key functional cytochrome P-450 derivatives detected Dispos dose respectively dose was excreted drug Key functional Drug Metab enantiomer enzyme epoxide ester ether excreted in urine extracted faeces formation formed fractions GC-MS glucuronide glucuronide conjugate glutathione glutathione conjugate guinea-pig H H H H OH hepatocytes HPLC human liver microsomes hydrolysis hydroxylation incubation inhibitor intermediate intraperitoneal intravenous isomers Key functional groups kidney liver microsomes Structure major metabolite male rats metabolites metabolites were identified metabolites were isolated methyl mg kg"1 mice Model compound Key monkey mouse liver N-oxide OH H oral administration oral dose oxidation perfused phenobarbital phenol plasma pretreatment rabbit rat liver microsomes Rat oral reference compounds side-chain species Structure and biotransformation substrate Test system tissue unchanged urinary metabolites Use/occurrence vivo Xenobiotica