Bisphosphonates and Osteonecrosis of the Jaw

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John P. Bilezikian, John T. Grbic
Wiley, Mar 14, 2011 - Medical - 87 pages
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In the last several years, reports of patients treated with bisphosphonates (primarily those delivered intravenously) have emerged associating their use with osteonecrosis of the jaw (ONJ). More than a thousand cases of bisphosphonate-associated ONJ have been identified since the first cases were reported in 2001. In these, ONJ rarely occurs "spontaneously"; the vast majority have been associated as a consequence to oral surgical procedures. Although most of the reports of ONJ have occurred in patients following the use of high dose IV therapy for metastatic bone disease, there are also reports of ONJ in patients taking oral bisphosphonates. Since millions of patients take oral bisphosphonates for the treatment of osteoporosis, it is timely to review what is known and needs to be learned about this emerging issue in patient care--to develop a consensus on the definition of ONJ, as well as to explore potential risk factors and pathogenic mechanisms of ONJ and to explore strategies to move research forward.

This volumes seeks to improve awareness of the condition and the need for increased screening and improved diagnosis of ONJ. It also explores possible treatment options for ONJ to help guide future areas for research.

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Contents

Use of bisphosphonates in the management of postmenopausal osteoporosis
15
Bisphosphonate use in conditions other than osteoporosis
33
Epidemiology and risk factors for osteonecrosis of the jaw in cancer patients
47
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About the author (2011)

Bilezikian, Departments of Medicine and Pharmacology, Division of Endocrinology, College of Physicians and Surgeons, Columbia University, New York.

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