Blood Substitutes: New Challenges

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Robert M. Winslow, Kim D. Vandegriff, Marcos Intaglietta
Springer Science & Business Media, Mar 28, 1996 - Medical - 210 pages
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This book is not a "proceedings" volume. Rather the chapters are essays by experts in the field of blood substitutes, invited by the editors to con tribute to the 1996 "Current Issues in Blood Substitutes Research and Development" course given in San Diego, March 18-21. The contributors were selected because of their expertise in areas deemed by the editors to be critical to the advancement of the field. The course, as in past years, is heavily influenced by feedback from par ticipants, and by research in this and related fields. In addition to the didactic lectures (for which these chapters are the foundation), the course also offers the opportunity for presentation of research reports, progress reports from the various companies currently commercializing products, and round table discussions of selected subjects. Thus, we are grateful to past participants for their helpful comments. Production of a book, especially on a short timeline, is not an easy feat.
 

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Contents

Blood Substitutes 1995 in the Literature
1
Blood Substitutes What is the Target?
15
Blood Flow Distribution During Shock
34
Blood Substitute Oxygen Carriers Designed for Clinical Applications
60
Interaction of Hemoglobin with Nitric Oxide and Carbon Monoxide Physiological Implications
74
Biological Consequences of Crosslinked Hemoglobin in Animal Models of Surgery and Endotoxemia
99
Hemorrhagic Disorders After Administration of Glutar aldehydepolymerized Hemoglobin
112
Microvascular Oxygen Distribution Effects Due to Free Hemoglobin in Plasma
124
Experimental Simulation of Oxygen Transport in Microvessels
132
Carbon Dioxide Transport by HemoglobinBased Blood Substitutes
146
Nonphospholipid Liposomes A Novel Method for the Preparation of Hemoglobin Containing Lipid Vesicles
163
HemoglobinEndotoxin Interactions
185
Index
203
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Page 200 - This work was sponsored by the Department of the Air Force under Air Force Contract No. F19628-00-C0002. The opinions, interpretations, conclusions, and recommendations are those of the authors and are not necessarily endorsed by the United States Air Force.
Page 179 - Diffusion of Univalent Ions Across the Lamellae of Swollen Phospholipids.

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