Blood Substitutes: New Challenges
Robert M. Winslow, Kim D. Vandegriff, Marcos Intaglietta
Springer Science & Business Media, Mar 28, 1996 - Medical - 210 pages
This book is not a "proceedings" volume. Rather the chapters are essays by experts in the field of blood substitutes, invited by the editors to con tribute to the 1996 "Current Issues in Blood Substitutes Research and Development" course given in San Diego, March 18-21. The contributors were selected because of their expertise in areas deemed by the editors to be critical to the advancement of the field. The course, as in past years, is heavily influenced by feedback from par ticipants, and by research in this and related fields. In addition to the didactic lectures (for which these chapters are the foundation), the course also offers the opportunity for presentation of research reports, progress reports from the various companies currently commercializing products, and round table discussions of selected subjects. Thus, we are grateful to past participants for their helpful comments. Production of a book, especially on a short timeline, is not an easy feat.
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Blood Substitutes 1995 in the Literature
Blood Substitutes What is the Target?
Blood Flow Distribution During Shock
Blood Substitute Oxygen Carriers Designed for Clinical Applications
Interaction of Hemoglobin with Nitric Oxide and Carbon Monoxide Physiological Implications
Biological Consequences of Crosslinked Hemoglobin in Animal Models of Surgery and Endotoxemia
Hemorrhagic Disorders After Administration of Glutar aldehydepolymerized Hemoglobin
Microvascular Oxygen Distribution Effects Due to Free Hemoglobin in Plasma
Experimental Simulation of Oxygen Transport in Microvessels
Carbon Dioxide Transport by HemoglobinBased Blood Substitutes
Nonphospholipid Liposomes A Novel Method for the Preparation of Hemoglobin Containing Lipid Vesicles
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amphiphiles animals aqueous arterial autologous Basis of Efficacy bilayer blood flow blood pressure blood substitutes blood transfusion capillary carbon cardiac output cell-free hemoglobin Clin clinical CO2 binding CO2 transport concentration coronary crease cross-linked curve decrease effect Efficacy R.M. Winslow encapsulated endothelial cells endothelium endotoxemia endotoxin erythrocytes factor Figure function guanylate cyclase HCO3 Hellums heme oxygenase hemodilution hemoglobin hemoglobin solutions hemorrhagic hypovolemia increased induced infusion inhibition Intaglietta interaction intestinal ischemia K.D. Vandegriff Kreimeier L-NAME leukocytes lipid liposome-encapsulated hemoglobin liposomes mechanism mediated membrane Messmer metabolism microcirculation microcirculatory microvascular moglobin molecular molecules Motterlini myocardial nitric oxide ooHb organ failure oxygen oxygen carrying oxygen delivery oxygen transport patients perfluorocarbon perfusion perioperative Ph.D phospholipid Physiol plasma platelet PolyHbXl polymerized potential protein rats reaction red blood cells red cell substitutes resuscitation role sepsis septic shock smooth muscle studies surgery surgical tion tissue toxic uptake vasoconstriction vesicles vivo
Page 200 - This work was sponsored by the Department of the Air Force under Air Force Contract No. F19628-00-C0002. The opinions, interpretations, conclusions, and recommendations are those of the authors and are not necessarily endorsed by the United States Air Force.