Body Composition and Aging

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C. V. Mobbs, Patrick R. Hof
Karger Medical and Scientific Publishers, 2010 - Medical - 197 pages
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Increased adiposity and decreased muscle mass contribute substantially to age-dependent disease and disability. In particular age-related increase in adiposity is quickly becoming a major threat to public health throughout the world. Although the hypothesis that age-related changes in body composition are due to lifestyle choices alone is well accepted, it is a vast oversimplification. This volume reflects the current knowledge in this rapidly developing field of research. The first part of the book discusses the extent to which increased adiposity contributes to age-related diseases and longevity. The 'obesity paradox', describing the protective role of overweight in decreasing mortality while increasing pathology, is covered in depth. Further chapters address specific aspects of the regulation of energy balance during aging, including the effects of changes in food intake. Finally the causes and consequences of loss of muscle mass and age-related osteoporosis are examined. A valuable help for physicians treating elderly patients, this book will also be of great interest to researchers studying energy balance, muscle physiology, bone disease, and other aspects of aging.
 

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Contents

Contribution of Adipose Tissue to Health Span and Longevity
1
Obesity Paradox during Aging
20
Central Control of Food Intake in Aging
37
Changes in Food Intake and Its Relationship to Weight Loss during Advanced Age
51
Changes in Body Composition in Response to Challenges during Aging in Rats
64
Using Caenorhabditis elegans to Identify Novel Targets for Ameliorating Body Composition Changes during Human Aging
84
Prevalence Mechanisms and Functional Consequences
94
mTOR Signaling as a Target of Amino Acid Treatment of the AgeRelated Sarcopenia
115
Mitochondrial Theory of Aging in Human AgeRelated Sarcopenia
142
Implications for Improving Healthy Aging and Longevity
157
Clinical Cellular and Molecular Phenotypes of Aging Bone
175
Author Index
193
Subject Index
194
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