Bone Formation

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Springer Science & Business Media, 2004 - Medical - 160 pages
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Bone research in recent years has generated much new knowledge, in large measure because of the broad public health implications of osteoporosis and related bone disorders. Bone Formation, the first in a series entitled Topics in Bone Biology, evaluates this new information and formulates novel insights and hypotheses within the broad framework of current knowledge. An easy-to handle and to read work, with concise reviews that are extensively referenced, the chapters in this book are written by internationally known authorities. Particular emphasis is on osteoporosis and related disorders of diminished bone formation. Among the general topics treated is a chapter on biomechanical aspects of bone formation, not often considered in relation to diseases of bone formation. The book constitutes essential reading for those entering the field of bone biology and those who wish to become familiar with up-to-date information in a particular area of bone research.
 

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Contents

1 Molecular Regulation of Osteoblast Differentiation
1
2 In Vitro Regulation of Osteoblast Activity
18
3 Systemic and Local Regulators of Bone Remodeling
44
4 Sitespecific Mineralized Matrix Formation by Osteoblasts
71
5 Biomechanical Aspects of Bone Formation
79
6 Reduced Bone Formation in the Pathogenesis of Bone Fragility
106
7 Diseases of Excess Bone Formation
120
8 Targeting the Osteoblast for Prevention and Treatment of Bone Diseases
138
Index
155
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About the author (2004)

Series Editors of Topics in Bone Biology are: Professors Felix Bronner, PhD - University of Connecticut Health Center, Farmington, CT, USA, and Dr Mary C. Farach-Carson, PhD - the Department of Biology, University of Delaware, Newark, DE, USA. In this fourth volume, the Series Editors are joined by a co-editor with special expertise in the volume topic, Dr Richard F. Loeser, MD, the Robert S. Katz, MD - Joan and Paul Rubschlager Presidential Professor of Osteoarthritis Research in the Department of Internal Medicine, Section of Rheumatology with a conjoint appointment in the Department of Biochemistry, Rush University, Chicago, IL, USA.