Bone research in recent years has generated much new knowledge, in large measure because of the broad public health implications of osteoporosis and related bone disorders. Bone Formation, the first in a series entitled Topics in Bone Biology, evaluates this new information and formulates novel insights and hypotheses within the broad framework of current knowledge. An easy-to handle and to read work, with concise reviews that are extensively referenced, the chapters in this book are written by internationally known authorities. Particular emphasis is on osteoporosis and related disorders of diminished bone formation. Among the general topics treated is a chapter on biomechanical aspects of bone formation, not often considered in relation to diseases of bone formation. The book constitutes essential reading for those entering the field of bone biology and those who wish to become familiar with up-to-date information in a particular area of bone research.
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1 Molecular Regulation of Osteoblast Differentiation
2 In Vitro Regulation of Osteoblast Activity
3 Systemic and Local Regulators of Bone Remodeling
4 Sitespecific Mineralized Matrix Formation by Osteoblasts
5 Biomechanical Aspects of Bone Formation
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activity anabolic apoptosis autosomal Biochem Biol Chem BMPs bone cells bone formation bone loss bone marrow bone mass bone matrix Bone Miner Res bone morphogenetic proteins bone remodeling bone resorption bone tissue Ca2+ Calcif Tissue Int calcium calvaria cartilage CBFA1 Cbfal cellular chondrocytes Clin Invest collagen cultures cytokines decreased disease dysplasia effects endochondral endocortical Endocrinology estrogen extracellular fluid fractures function gene expression Genet glucocorticoid growth factor human osteoblasts increased bone induced inhibitory inhibits insulin-like growth interleukin-1 isoforms kinase leptin long bones MC3T3-E1 cells mechanical loading mediated membrane mesenchymal metabolism mice mouse mRNA murine mutations osteo osteoblast differentiation osteoblast-like cells osteocalcin osteoclast formation osteocytes osteogenic osteopontin osteoporosis osteoprotegerin osteosarcoma parathyroid hormone pathways periosteal phenotype Physiol proliferation prostaglandin protein PTHrP Raisz LG receptor regulation response role signaling skeletal stimulates strain studies surface syndrome synthesis thyroid hormone tion trabecular bone transcription factor vitamin vitro vivo