Brain Mapping: The Methods, Volume 1

Front Cover
Arthur W. Toga, John C. Mazziotta
Academic Press, Oct 9, 2002 - Medical - 877 pages

Investigation of the functional architecture of the human brain using modern noninvasive imaging techniques is a rapidly expanding area of research. A proper knowledge of methodology is needed to appreciate the burgeoning literature in the field. This timely publication provides an excellent catalogue of the main techniques.

The authors offer an invaluable analysis of mapping strategies and techniques, providing everything from the foundations to the major pitfalls and practical applications of the modern techniques used in neuroimaging. Contains over 1000 full color pages with more than 200 color figures.



Spanning the methodological gamut from the molecular level to the whole brain while discussing anatomy, physiology, and pathology, as well as their integration, Brain Mapping: The Methods, Second Edition, brings the reader a comprehensive, well-illustrated and entirely readable description of the methods for brain mapping. Drs. Toga and Mazziotta provide everything from the foundations to the major pitfalls and practical applications of the technique by assembling an impressive group of experts, all widely known in their field, who contribute an outstanding set of chapters.
 

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Contents

Introduction
3
Time and Space
33
Optical Imaging of Neural Structure
49
Imaging Methodology
57
Conclusions and Future Prospects
71
Voltage and Calcium Imaging of Brain
77
Light Sources
83
Calcium Dye Recording in the Mouse Olfactory
89
CT Angiography and
427
Acquisition Postprocessing
456
Clinical Utility
462
Imaging Brain Function with Positron
485
Tracer Kinetic Models
498
VIII
504
Devous
513
Jacopo Annese and Arthur W Toga
537

Cheney 189 Angeles California 900951770
94
Optical Imaging Based on Intrinsic Signals
97
Data Analysis for Mapping Functional
114
Chronic Optical Imaging
121
Applications
130
Conclusions and Outlook
136
Other Optical Parameters Relevant for Near
143
Dynamic Measurements of Local
159
Diameter 1 65
165
Electrophysiological Imaging
175
Analysis of Functional Networks
183
Electrophysiological Methods for Mapping
189
Electrical Stimulation and Other Input
195
Mapping Motor Output with Electrical
205
Mapping Motor Output with HighDensity
211
Comparison of Results from SpikeTriggered
219
Magnetoencephalographic
227
Instrumentation and Data Acquisition
233
Conclusions and Future Directions
248
Introduction
255
VII
286
Functional
313
ReSolution
336
Magnetic Resonance Spectroscopic
351
Applications
371
Principles Methods and Applications
379
Resonance Imaging
399
T and T2Induced Contrasts
407
Concluding Remarks
419
Ouantitative Analysis of Cyto
573
References
599
Experimental Design
605
Designing fMRI Studies
618
Inferences about Subjects
624
Correlation of Brain
633
Clinical Examples of Intrasubject Multimodal
640
Intersubject Multimodal Integration
649
Advanced Nonrigid Registration
661
Registration of Diffusion Tensor
677
The MongeKantorovich Problem and Image
683
Conclusion
702
Joseph A Duimstra 819 Karl Heinz Höhne 707
707
Segmentation
709
Intelligent Visualization
718
The International Consortium for Brain
727
Methods and Results 74 1
741
Conclusions
750
Subpopulation Brain Atlases
757
Population Maps of the Cortex
766
Probabilistic Atlases 775 Applications
813
Subpopulation Selections 786
819
Gobalakrishnan Sundaresan and Sanjiv S Gambhir V Magnetic Resonance Spectroscopy and Gene
825
Application of in Vivo Reporter Gene Imaging to I ducti
831
Their
840
Antisense Reporter Probes for Imaging IV Conclusion
853
Nonradionuclide Approaches to Reporter Gene
859
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About the author (2002)

Dr. Mazziotta is a Professor of Neurology, Radiological Sciences, and Pharmacology and the Pierson Lovelace Investigator at UCLA, as well as the Director of the UCLA Brain Mapping Program that he established in 1993. Dr. Mazziotta has published more than 190 research papers and five texts and has received numerous honor and achievement awards including the Oldendorf Award of the American Society of Neuroimaging, the S. Weir Mitchell Award of the American Academy of Neurology, and the Von Hevesy Prize from the International Society of Nuclear Medicine. Dr. Mazziotta has been chair of the Scientific Issues and Program Committee of the American Academy of Neurology. He is the President-Elect of the American Neuroimaging Society and is the President of the Brain Mapping Medical Research Organization. He is also Co-Editor-in-Chief of NeuroImage.

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