Brain Slices in Basic and Clinical Research

Front Cover
CRC Press, Apr 13, 1995 - Science - 352 pages
Brain Slices in Basic and Clinical Research describes advancements in the field of brain function and dysfunction through use of central nervous system slice preparations. Topics are authored by leading scientists and include the following:
  • Mechanisms of synaptic plasticity as the basis of memory processes
  • Chaos and synaptic variability
  • Brain calcium currents
  • Glutamate receptors
  • Pathophysiology of excitotoxins
  • Cerebral hypoxia-ischemia
  • Neuronal injury
  • Free radicals
  • Optical methods of measuring brain metabolism
  • Voltammetry in brain slices
  • Calcium imaging
  • Patch-clamp recording and application of macromolecules through patch-clamp pipettes in brain slices
  • Intracellular double labeling of various neuronal populations
  • Use of brain slices in teaching neurophysiological methods
    Most of the topics are published in book format for the first time, and some of the techniques are more fully detailed than in any other book.
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    Contents

    Advances in Understanding the Mechanisms Underlying
    2
    Calcium Dependency of Synaptic Plasticity
    9
    Multiple Plasticity Model
    16
    References
    22
    Chaotic Components of Synaptic Variability in Hippocampal
    27
    Useful Indices
    47
    Voltammetry in Brain Slices
    65
    PatchClamp Recording in Brain Slices
    99
    The Importance of Temperature Control When Investigating
    149
    A Neurochemical Approach to Elucidate Metabotropic
    171
    Radiotracer Labeling of Brain Slices
    187
    The Pharmacology of Excitotoxins and Energy Deprivation
    221
    Delayed Neuronal Injury in the Hippocampal Slice
    243
    Gene Expression as an Index of Pathophysiology Associated
    257
    Studies on Anoxic Depolarization
    273
    The Use of Brain Slices in the Study of Free Radical Actions
    295

    Intracellular Application of Macromolecules Through Patch
    117
    Intracellular Double Labeling of Substantia Nigra
    131
    Using the In Vitro Hippocampal Slice as a Model to Teach
    313
    Copyright

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