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Cellular Work in the Brain
Circulation and Oxygen Consumption in the Brain
Utilization of Substrates by Brain Tissues
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a-KG acid cycle intermediates acidosis activity alanine amino acids ammonia anaesthesia anaesthetics animals arterial aspartate barbiturates blood flow brain tissue calculated catalysed CBF and CMR02 cell cerebral cortex cerebral metabolism changes Chapter citric acid cycle CMRgl CO2 tension complete ischemia cortical cytoplasmic decrease dehydrogenase discussed effect energy metabolism enzyme equation equilibrium Figure flux Folbergrova function GABA glial glucose concentration glucose consumption glucose transport glutamate glutamine glycogen glycolysis glycolytic halothane hypercapnia hypoglycemia hypothermia hypoxia increase in CBF indicate induced inhibition intracellular ischemia Kety and Schmidt lactate lactate concentration measurements mechanisms membrane metabolic rate metabolites method Michenfelder mitochondria mitochondrial molecules NAD+ NADH neurons normal occurs oxidation oxygen oxygen consumption pathway perfusion phenobarbital phosphate phosphorylation pyruvate reaction redox reduced Reproduced with permission respiratory results obtained seizures Siesjo studies substrate synthesis technique temperature tion tissue concentrations uptake values vitro vivo