Bridging the Bed-Bench Gap: Contributions of the Markey Trust

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National Academies Press, Feb 5, 2004 - Medical - 134 pages
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Since the 1970s there has been a serious gap between fundamental biological research and its clinical application. In response to this gap the Lucille P. Markey Charitable Trust instituted the General Organizational Grants program, which funded two types of awards to provide training that would bridge the bed-bench gap. These training awards fell into two categories: (1) those that provided significant opportunities for M.D.s to engage in basic research during and immediately following medical school and residency, and (2) those that provided significant clinical exposure for Ph.D.s while they were predoctoral or postdoctoral students. These grants were intended to close the widening gap between rapid advances in our understanding of the biological process and the translation of that knowledge into techniques for preventing diseases. This report examines the General Organizational Grant programs, identifies best practices, and provides observations for future philanthropic funders.

 

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Contents

Executive Summary
1
Introduction
6
History of the Markey Trust
8
Grant Programs
13
Assessing the Markey General Organizational Grants Program
19
The Biomedical Research Environment in the 1980s
22
Closing the BedBench Gap
24
The Current Biomedical Research Environment
32
Appendixes
43
A Bridge Building Between Medicine and Basic Science
45
Opportunities for Revitalization Emerge
60
C Workshop on Training Programs in PatientOriented Pathobiology for Basic Scientists
69
D Workshop on Training Programs in PatientOriented Pathobiology for Basic Scientists
71
E Descriptions of Programs Participating in the Workshop on Training Programs in PatientOriented Pathobiology for Basic Scientists
74
F Summary of Site Visits to MarkeyFunded Programs That Provided Training in Basic Research to Physicians
109
G Biographies of Members of the Lucille P Markey Charitable Trust Programs in Biomedical Sciences Committee
121

Conclusions and Observations for Philanthropic Funders
35
References
40

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