Bursting: The Genesis of Rhythm in the Nervous System

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World Scientific, 2005 - Science - 401 pages
Neurons in the brain communicate with each other by transmitting sequences of electrical spikes or action potentials. One of the major challenges in neuroscience is to understand the basic physiological mechanisms underlying the complex spatiotemporal patterns of spiking activity observed during normal brain functioning, and to determine the origins of pathological dynamical states such as epileptic seizures and Parkinsonian tremors. A second major challenge is to understand how the patterns of spiking activity provide a substrate for the encoding and transmission of information, that is, how do neurons compute with spikes? It is likely that an important element of both the dynamical and computational properties of neurons is that they can exhibit bursting, which is a relatively slow rhythmic alternation between an active phase of rapid spiking and a quiescent phase without spiking. This book provides a detailed overview of the current state-of-the-art in the mathematical and computational modeling of bursting, with contributions from many of the leading researchers in the field.
 

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Contents

THE DEVELOPMENT OF THE HINDMARSHROSE MODEL FOR BURSTING
3
NEGATIVE CALCIUM FEEDBACK THE ROAD FROM CHAYKEIZER
19
AUTOREGULATION OF BURSTING OF AVP NEURONS OF THE RAT HYPOTHALAMUS
49
BIFURCATIONS IN THE FAST DYNAMICS OF NEURONS IMPLICATIONS FOR BURSTING
89
BURSTING IN 2COMPARTMENT NEURONS A CASE STUDY OF THE PINSKYRINZEL MODEL
123
GHOSTBURSTING THE ROLE OF ACTIVE DENDRITES IN ELECTROSENSORY PROCESSING
145
BURSTING AT THE NETWORK LEVEL
173
ANALYSIS OF CIRCUITS CONTAINING BURSTING NEURONS USING PHASE RESETTING CURVES
175
BURSTING IN COUPLED CELL SYSTEMS
201
MODULATORY EFFECTS OF COUPLING ON BURSTING MAPS
223
BEYOND SYNCHRONIZATION MODULATORY AND EMERGENT EFFECTS OF COUPLING IN SQUAREWAVE BURSTING
243
BURSTING IN EXCITATORY NEURAL NETWORKS
273
OSCILLATORY BURSTING MECHANISMS IN RESPIRATORY PACEMAKER NEURONS AND NETWORKS
303
GEOMETRIC ANALYSIS OF BURSTING NETWORKS
347
ELLIPTIC BURSTERS DEPOLARIZATION BLOCK AND WAVES
385
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