Calcium, Oxygen Radicals and Cellular Damage

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C. J. Duncan
Cambridge University Press, Jan 28, 2008 - Medical - 240 pages
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The cellular events underlying rapid cellular damage in different organs are potentially of great medical importance, for example muscular dystrophy, liver damage and the preservation of kidneys for transplantation. Many hypotheses exist for the biochemical pathways involved in these damage processes. The roles of calcium and active oxygen metabolites are of particular interest. There is considerable literature on both these triggering agents and good evidence for their involvement in the genesis of damage, although little agreement on their precise roles. This volume records the proceedings of a meeting held by the Society for Experimental Biology that attempted to determine whether there are common mechanisms of cellular damage and to explore the ways in which calcium and oxygen radicals may interact to generate damage. The questions addressed, in particular, are whether there are any common biochemical pathways, and the specific and possibly interacting roles of calcium and active oxygen metabolites.
 

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Contents

Are there common biochemical pathways in cell damage and cell death?
1
Free radicals in the pathogenesis of tissue damage
11
Calcium and signal transduction inoxidative cell damage
17
Regulation of neutrophil oxidant production
35
role of oxidant stress
77
Biochemical pathways that lead to the release of cytosolic proteins in the perfused rat heart
97
the roles of free radicals and calcium?
115
Free radicals calcium and damage in dystrophic and normal skeletal muscle
139
Ultrastructural changes in mitochondria during rapid damage triggered bycalcium
149
The importance of oxygen free radicalsiron and calcium in renal ischaemia
165
a quantal framework for understanding the molecular pathway of cell activation and injury
189
Index
218
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