Calcium, Oxygen Radicals and Cellular Damage
C. J. Duncan
Cambridge University Press, Jan 28, 2008 - Medical - 240 pages
The cellular events underlying rapid cellular damage in different organs are potentially of great medical importance, for example muscular dystrophy, liver damage and the preservation of kidneys for transplantation. Many hypotheses exist for the biochemical pathways involved in these damage processes. The roles of calcium and active oxygen metabolites are of particular interest. There is considerable literature on both these triggering agents and good evidence for their involvement in the genesis of damage, although little agreement on their precise roles. This volume records the proceedings of a meeting held by the Society for Experimental Biology that attempted to determine whether there are common mechanisms of cellular damage and to explore the ways in which calcium and oxygen radicals may interact to generate damage. The questions addressed, in particular, are whether there are any common biochemical pathways, and the specific and possibly interacting roles of calcium and active oxygen metabolites.
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Other editions - View all
active oxygen arrhythmias Biochemical Journal Biochemistry Biological Chemistry Ca2+-paradox calcium Campbell cardiac Cellular Cardiology cellular damage chronic granulomatous disease CK release Clinical Investigation components cytosolic deﬁciency Duncan Duthie dystrophy efﬂux electron enzyme ﬁgures free Ca2+ free radicals free-radical function glutathione Gutteridge Halliwell halothane Hearse hepatocytes homeostasis human neutrophils increased incubated induced inhibition inhibitor injury intracellular Ca2+ iron ischaemia ischaemic Jones Journal of Biological Journal of Clinical Journal of Molecular kidneys leukocytes lipid bodies lipid peroxidation lysosomal malignant hyperthermia mechanisms metabolism MH/PSS mitochondria modiﬁcation Molecular and Cellular muscle cells myoﬁlament NADPH oxidase neutrophils Nicotera organelles Orrenius oxidant stress oxidase activation oxygen paradox oxygen radicals pathways perfused phagocytic phospholipase A2 phosphorylation plasma membrane potential production prostaglandin proteases protein kinase rat heart reactive receptor reperfusion Research respiratory burst rise in Ca2+ role rubicon sarcolemma sarcoplasmic reticulum Segal signal skeletal muscle speciﬁc stimulated superoxide thiol tion tissue ultrastructural vitamin vitamin E vitro