Camptothecins in Cancer Therapy

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Val R. Adams
Springer Science & Business Media, Oct 27, 2007 - Medical - 460 pages
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A critical review our current understanding of camptothecins, their shortcomings, and of the possibilities for improving their clinical performance. The authors discuss new camptothecin analog development, drug delivery issues for optimizing their anticancer activity, and their potential use in a variety of different cancers. Additional chapters describe what is known about the biochemistry, the pharmacology, and the chemistry of the camptothecins, including the mechanism of topoisomerase and how camptothecins poison this enzyme, the use of animal models in defining the anticancer potential of camptothecins, and the question of camptothecin resistance.
 

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Contents

VI
3
VIII
23
XI
39
XIV
61
XVII
109
XX
127
XXIII
153
XXVI
171
XXXIV
207
XXXVIII
229
XL
263
XLIII
301
XLVII
317
L
343
LIII
369
LVI
421

XXIX
191
XXX
193

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Page v - I do not feel obliged to believe that the same God who has endowed us with sense, reason, and intellect has intended us to forgo their use.
Page 458 - Induction of endonucleolytic DNA cleavage in human acute myelogenous leukemia cells by etoposide, camptothecin, and other cytotoxic anticancer drugs: A cautionary note. Cancer Res. 49, 5870-5878.
Page 15 - Plant antitumor agents. I. The isolation and structure of camptothecin, a novel alkaloidal leukemia and tumor inhibitor from Camptotheca acuminata.

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