The fourth edition of this classic text provides a thorough, yet concise review of the cellular and molecular mechanisms involved in the transformation of normal into malignant cells, the invasiveness of cancer cells into host tissues, and the metastatic spread of cancer cells in the host organism. It defines the fundamental pathophysiologic changes that occur in tumor tissue and in the host animal or patient. Each chapter discusses the historical development of a field, citing the key experimental advances to the present day, and evaluates the current evidence that best supports or rules out concepts of the molecular and cellular mechanisms regulating cancer cell behavior. For all the areas of fundamental cancer research, an effort has been made to relate basic research findings to the clinical disease states. The book is well written and well illustrated, with schematic diagrams and actual research data to demonstrate points made in the text. There is also an extensive, up-to-date bibliography, making the book valuable to scientists, and to physicians, students, and nurses interested in the field of cancer biology. The topics covered include pathologic characterization of human tumors, epidemiology of human cancer, regulation of cell proliferation and differentiation, cellular and molecular phenotypic characteristics of the cancer cell, mechanisms of carcinogenesis, tumor initiation and promotion, viral carcinogenesis, oncogenes and oncogene products, growth factors, chromosomal alterations in cancer, mechanisms of tumor metastasis, host-tumor interactions, fundamental aspects of tumor immunology, and the advances in cancer cell biology that will lead to improved diagnosis and treatment of cancer in the future.
What people are saying - Write a review
We haven't found any reviews in the usual places.
1 CHARACTERISTICS OF HUMAN CANCER
2 CAUSES OF CANCER
3 THE EPIDEMIOLOGY OF HUMAN CANCER
4 THE BIOCHEMISTRY AND CELL BIOLOGY OF CANCER
5 MOLECULAR GENETICS OF CANCER
6 TUMOR IMMUNOLOGY
Other editions - View all
Acad Sci USA activity agents alterations amino acid angiogenesis antigens apoptosis binding breast cancer cancer cells Cancer Res carcinogenic carcinoma cell cycle cell lines cell proliferation cell surface cell types cellular chemical chromatin chromosome clinical colon colorectal complex cyclin detected differentiation disease DNA methylation domain drug enzymes example exposure fibroblasts function gene expression genetic genome growth factor histone hormone human cancers increased induced inhibit inhibitors interactions invasive involved leukemia liver lung cancer lymphocytes lymphoma malignant mechanisms melanoma metastasis metastatic methylation mice molecular molecules mouse mRNA mutations Natl Acad Sci Natl Cancer Inst neoplastic NF-kB normal occur oncogene overexpressed pathway peptides phenotype phosphorylation Proc Natl Acad produce prostate cancer receptor regulation reviewed in Reference risk role sarcoma sequences signal specific stem cells stimulate studies target therapy tion tissue transcription factors transformation translocation tumor cells tumor suppressor gene tyrosine kinase viral virus viruses vivo yeast