Cancer Chemotherapy and Biotherapy: Principles and Practice
Bruce Chabner, Dan Louis Longo
Lippincott-Raven Publishers, 1996 - Biological products - 824 pages
This text presents a detailed description of the properties and clinical use of anticancer drugs. It provides information on all aspects of drug mechanisms of action, interactions with other agents, toxicities, side effects, and mechanisms of resistance. Emphasis is placed on the rationale for the use of drugs in specific schedules and combinations, and guidelines are provided by dose adjustment in particular situations. This edition includes chapters on the following: endocinre therapies; antifolates; fluropyrimidines; cytidines and purine analogues; hydroxyurea; mitotic inhibitors; alkylating agents; antitumour antibiotics; anthracyclines; topoisomerase inhibitors; enzyme therapy; and anti-AIDS drugs.
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J Jerry M Collins
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27 other sections not shown
5-fluorouracil acid acute adducts administration alkylating agents allopurinol analogues anthracyclines anticancer antitumor activity araC assay binding Biochem Pharmacol Biol Chem bleomycin bolus bone marrow breast cancer cancer cells Cancer Chemother Pharmacol Cancer Res Cancer Treat Rep carcinoma cell lines cellular chemotherapy cisplatin clearance Clin Oncol clinical trials compounds concentrations cyclophosphamide cytotoxicity dacarbazine decreased DHFR dose doxorubicin drug effects enzyme estrogen etoposide excretion exposure FdUrd folate function gene half-life hepatic high-dose hormone human hydroxyurea increased infusion inhibition inhibitor interactions intracellular intravenous kinase kinetics leucovorin leukemia leukemia cells liver lymphoma malignant metabolism metabolites methotrexate microtubule mitomycin murine Natl normal nucleotide oral ovarian paclitaxel patients receiving pharmacokinetics pharmacology phase polyglutamates Proc procarbazine prostate protein pulmonary reactions receptor reductase regimens renal resistance schedule sensitivity steroid studies synthesis tamoxifen Taxol therapy thymidylate tion tissues top2 topoisomerase toxicity treatment tumor tumor cells Vinca alkaloids vincristine vitro vivo