Cancer Clinical Pharmacology

Front Cover
Jan H. M. Schellens, Howard L. McLeod, David R. Newell
OUP Oxford, May 5, 2005 - Medical - 267 pages
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Cancer Clinical Pharmacology provides a comprehensive account of the scientific basis of anti-cancer therapy in patients with solid tumours and haematological malignancies. An international group of experts have brought together information on the basic principles of pharmacology and tumour biology, bioanalytical aspects, pharmacokinetics, and the pharmacodynamics of anti-cancer agents. The clinical pharmacology of individual anti-cancer agents are covered, including the most important recently registered novel anti-cancer drugs. This book will prove an invaluable source of information for all trainees in oncology, haematology and internal medicine. Since cancer clinical pharmacology is a vast subject this book will be useful for all individuals involved in cancer pharmacology such as nurses, pharmacists, general pharmacologists, and cancer scientists.
 

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Contents

Bioanalytical methods for anticancer drugs
1
Principles of pharmacokinetics
18
Clinical implications and mechanisms of variability in the response to anticancer agents
30
Drug development and study design
41
Pyrimidine antimetabolites
51
Purine analogs and antifolates
63
Alkylating agents
84
Epipodophyllotoxins
104
Taxanes
134
Vinca alkaloids
150
Topoisomerase I targeting agents
164
Platinum agents
185
focus on imatinib and gefitinib
198
Antiendocrine drugs used in cancer treatment
216
The clinical application of tumour biology
238
Index
260

Anthracyclines
117

Common terms and phrases

About the author (2005)

Jan H M Schellens is a Consultant Medical Oncologist and Clinical Pharmacologist, The Netherlands Cancer Institute, Amsterdam and the Faculty of Pharmaceutical Sciences, Division of Drug Toxicology, University Utrecht, Utrecht, The Netherlands. Howard McLeod is an Associate Professor,Washington University School of Medicine, St. Louis, Missouri, USA.

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