Cancer Diagnostics with DNA Microarrays

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John Wiley & Sons, Nov 3, 2006 - Science - 272 pages
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Authored by an international authority in the field,Cancer Diagnostics with DNA Microarrays is a complete reference work on the rapidly growing use of DNA microarray data in the diagnosis of and treatment planning for a large number of human cancers.
  • Uniquely deals with direct clinical application of microarray data to oncology diagnosis, leading to more effective diagnosis of and clearer treatment regimens for a wide range of human cancers
  • Offers clinicians summary presentation of state-of-the-art science of DNA microarrays
  • Each chapter includes bibliographic and further reading suggestions
  • Easily accessible, assuming no special training in statistics or bioinformatics

Replete with examples and mini-cases, Cancer Diagnostics with DNA Microarrays offers cancer researchers in private, pharmacologic, and governmental institutions, biomedical statisticians, and practicing oncologists concise, thoughtfully authored guidance on the use of microarray data and analysis as clinical tools. The text carefully addresses the needs of end users – researchers and physicians – using microarrays as a tool to be applied in common clinical situations, and is of interest for students in medicine and biology and professionals in health care as well.

 

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Contents

1 Introduction to DNA Microarray Technology
1
2 Image Analysis
16
3 Basic Data Analysis
22
4 Visualization by Reduction of Dimensionality
37
5 Cluster Analysis
44
6 Molecular Classifiers for Cancer
54
7 Survival Analysis
66
8 MetaAnalysis
69
14 Lung Cancer
114
15 Bladder Cancer
123
16 Colon Cancer
127
17 Ovarian Cancer
130
18 Prostate Cancer
134
19 Melanoma
138
20 Brain Tumors
142
21 Organ or Tissue Specific Classification
147

9 The Design of Probes for Arrays
73
10 Software Issues and Data Formats
78
11 Breast Cancer
87
12 Leukemia
97
13 Lymphoma
104
22 Sample Collection and Stability
149
References
152
Index
183
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About the author (2006)

STEEN KNUDSEN, PhD, is Director of Research at the Medical Prognosis Institute where he is now taking DNA microarrays into the clinic. Dr. Knudsen is a pioneer in the field of bioinformatics, having published a groundbreaking paper in Nature in 1990. He is also author of the critically acclaimed Guide to the Analysis of DNA Microarray Data (Wiley).

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