Cancer and Inflammation

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Douglas W. Morgan, Ulf J. Forssman, Marian T. Nakada
Springer Science & Business Media, Jul 23, 2004 - Medical - 202 pages

How are cancer and inflammation interrelated mechanistically and clinically? Though extensive literature exists on the topic "Cancer and Inflammation", there are relatively few texts that have truly integrated the two in spite of the many common mechanisms shared by their processes. Certainly, areas such as cytokines, growth factors, proliferation, signal transduction and angiogenesis, for example, are found in both. Yet, the dynamics of how these common mechanisms are maybe interrelated in the pathologies of the two is not widely covered. Such coverage, as presented in this volume, may help further understanding and bring new approaches to therapeutics.

The first section of the book discusses inflammatory mechanisms, studied in cellular and animal studies. The second part concentrates on clinical studies with antiinflammatory drugs in cancer treatment. The volume is written for biomedical researchers in the health care industry and in academia who are working in these areas.

 

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Contents

Chronic inflammation and cancer in various organ systems
1
role of immunotherapy
21
their role in tumor growth and progression
53
implications for cancer development
71
Interplay between inflammation and tumor angiogenesis
99
Apoptotic responses common to cancer and inflammation
123
prospects as a therapeutic target
147
Effects of COX2 inhibitors in colorectal cancer
177
Inflammation necrosis and cancer
189
Index
197
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