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5-fluorouracil acute GVHD acute leukemia adjuvant chemotherapy adjuvant therapy administration agents analysis ANLL antibody antigen auto-BMT autologous BMT autologous bone marrow BCR-ABL bolus bone marrow transplantation breast cancer cell lines chronic Clin Oncol clinical trials colonic cancer colony stimulating factor colorectal cancer combination complete remission cyclophosphamide cytotoxic difference disease-free survival Dr Morstyn drug effect evaluated G-CSF gastric cancer grade graft graft-versus-host disease granulocyte GVHD hematopoietic high dose high-dose HLA match Hospital host disease incidence infusion Japan leucovorin leukemic cells levamisole locus mismatch lymphocytes lymphoma malignant matched sibling McGlave median methotrexate minimal residual disease modulation myeloid Nagoya neutropenia neutrophil Oncology patients receiving phase platelet purging randomized rectal cancer regimen relapse rate response rate rhG-CSF Santos GW solid tumors stem cells surgical adjuvant survival rate Table toxicity treated treatment unrelated donors vitro