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Introduction to the Concept and Practice of Infusion
Technologic Impetus to Infusional Chemotherapy
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5-fluorouracil achieved administered ara-C BCNU Bleomycin bolus bolus injection bolus schedule breast cancer carcinoma cardiac toxicity catheter cell chemotherapy Cisplatin clinical trials colorectal cancer compared concentration cycle cyclophosphamide cytotoxic delivered delivery demonstrated disease dose rate dose-limiting Doxorubicin drug duration effects Etoposide evaluated exposure FUDR half-life head and neck hepatic artery high-dose I.a. infusion I.v. bolus infu infusion chemotherapy infusion therapy infusional intra-arterial investigators leucovorin leukemia leukopenia levels liver lung lymphoma malignant median survival melanoma metastases Methotrexate mg/kg/day mg/ml Mitomycin-C months myelosuppression neck cancer needle objective response observed occlusion patients receiving patients treated patients with advanced pharmacokinetic phase 1 study phase 2 trials plasma portal protracted infusion radiation randomized regimen regional reported response rate sarcoma significant squamous stomatitis streptozotocin surgery Table therapeutic therapeutic index tion tissue toxicity treatment tumor venous Vinblastine vincristine vitro