Cancer Diagnostics: Current and Future Trends
Robert M. Nakamura, Wayne W. Grody, James T. Wu, Raymond B. Nagle
Humana Press, Jul 16, 2004 - Medical - 508 pages
Advances in diagnostic technology during the past several years have significantly enhanced our ability to detect human cancers in the very early stages of tumor formation. In Cancer Diagnostics: Current and Future Trends, high-profile laboratory scientists and basic cancer researchers review those recent and emerging clinical laboratory tests that can help in the early detection, evaluation, and prediction of human tumors, and so permit more informed therapeutic decisions. Emphasizing the importance of molecular and genetic RNA/DNA tests that can detect persons at high risk for specific cancers, the authors explore these novel serological assays, cellular assays useful for anatomic pathology, and molecular and genetic assays. Highlights include a profile of genetic tests for the diagnosis of colon, lung, and pancreatic cancers and a discussion of the molecular microsatellite instability that is observed in many cancers and permits the diagnosis of particular cancers.
Informative and state-of-the-art, Cancer Diagnostics: Current and Future Trends thoroughly treats the best current methods for cancer diagnosis and monitoring, and points to a future in which early diagnosis and detection of cancer will become a reality.
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General Considerations in the Use and Application of Laboratory Tests
The Changing Role of the Pathologist in the Management
Types of Circulating Tumor Markers
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abnormalities acute adenomas allelic alterations amplification analysis antibodies antigen assay assessment associated benign Biol biopsy blood BRCA1 BRCA2 breast cancer cancer patients Cancer Res chemotherapy chromosome Clin clinical colon colorectal cancer correlation cytogenetic detection diagnostic evaluation flow cytometry genetic genomic growth factor HER2 hnRNP A2/B1 human hybridization identified immunophenotyping k-ras laboratory leukemia levels lung cancer lymphocytes lymphoma malignant melanoma metastases methylation microarray microsatellite instability molecular monitoring mRNA mutations nonseminomatous normal oncogene Oncol ovarian cancer overexpression pancreatic Pathol phenotype plasma polyposis predict prognostic prostate cancer prostate-specific antigen protein proteomics rearrangements receptor residual disease risk RT-PCR seminoma sensitivity serum serum AFP serum HCG serum LD serum LD-1 serum tumor markers serum tumor-marker specific stage studies syndrome T-cell target technique telomerase testicular germ-cell tumors therapy tion tissue translocations tumor cells tumor markers tumor suppressor genes tumor-marker tests Urol