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Specific Questions Relating to Drug Treatment of Advanced Clinically
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activity adriamycin alkylating agents animals anticancer drugs antimetabolite antineoplastic antitumor Ara-C bleomycin bone marrow breast cancer Cancer Chemother Cancer Chemotherapy Cancer Philadelphia Cancer Res Cancer Treat cellular clearance combination chemotherapy compared compounds cure curve cyclophosphamide Daunomycin disease dose drug treatment effects enzyme evaluation example excretion experimental exponential factors fluorouracil Frei Freireich Gompertzian growth fraction Guarino increase individual tumor initial kidney levels liver lung lymphoma M. D. Anderson Hospital major MEDIAN LIFE SPAN metabolism metabolites methotrexate MG/KG mice monkey murine neoplastic nitrosoureas number of patients observed occur osteogenic sarcoma pharmacokinetic Pharmacol pharmacologic Phase I trial phenomenological physician plasma predictive prednisone Procarbazine randomized clinical trial RANGE OF DEATHS ratios renal response rate Schabel schedule Schein shark solid tumors species Table testing therapeutic therapy tion tissues toxicity toxicologic tumor tumor cells tumor growth urine variable vincristine volume