Cancer Neutron Capture Therapy
There are many human cancers which actively synthesize specific characteristic proteins such as melanomas, thyroid cancer and squamous cell carcinoma. Many cancer researchers have of course tried to utilize this specific activity as a key for the selective treatment of cancers. In the past for example, the molecular hybrid compound of DOPA, a substrate of melanin, and nitrogen mustard N-oxide hydrochloride, a ctyotoxic anti-tumor drug, was synthesized as Melphalan and used to treat malignant melanoma. A major problem arose though in that it was soon found to be highly suppressive toward bone marrow and quite toxic while not being remarkably effective. Thus, malignant melanoma could not be cured by it. Such failure led us to develop a novel bimodal therapeutic system which includes the use of non-toxic potentially cytocidal chemicals which selectively accumulate within the cancer cells and which are converted by a controllable modality into an actively cytocidal element in situ. We can now non-surgically cure malignant melanoma and glioblastoma with our selective cancer treatment, neutron capture therapy (NCT); as can be found in this volume. Included are 124 papers on the latest breaking developments discussed at the Sixth International Symposium on NCT for Cancer held in Kobe during the late autumn of 1994.
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Selective Thermal Neutron Capture Therapy of Cancer Cells Using Their
NonLinear Regression between Track Density and IOB Concentration
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amino acids antibody aqueous binding biodistribution biological BNCT boric acid boron compounds boron concentration boron neutron capture boron-containing boronic acid brain tumor calculated Cancer Neutron Capture carborane carboranyl Chem chemical clinical complex conjugates core derivatives detector distribution DOPA dose rate dosimetry edited by Mishima epithermal neutron beam factor fast neutron fast neutron dose Figure gadolinium gamma rays glioma glioma cells human Ichihashi imaging incubated injection IOB concentration irradiation Japan Kyoto liposomes MCNP measured melanin melanoma cells method Mishima Plenum Press Mn-BOPP Monte Carlo Neutron Capture Therapy neutron energy neutron flux nuclear nucleosides o-BPA oxidation p-boronophenylalanine p-BPA patient Petten phenylalanine porphyrin proton radiation radioactivity ratio reaction receptor Research Reactor samples Soloway solution spectra spectrum studies synovium synthesis target Therapy for Cancer thermal neutron thermal neutron flux tissue treatment tumor cells tyrosinase tyrosine uptake York Yoshino