Cannabis and Cannabis-based Medicines: Potential Benefits and Risks to Health : Report of a Working Party
Royal College of Physicians, 2005 - Cannabinoids - 33 pages
This report takes an objective look at the evidence on cannabis-based medicines and their ability to treat conditions such as multiple sclerosis and chronic pain.
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Chemistry and pharmacology of cannabinoids
Cannabinoids as a treatment for chronic pain
Other potential medicinal uses of cannabinoids
Summary and conclusions
active agonists anandamide animal models antagonists Anti-emetic appetite Ashworth scale assessing associated Box Scale brain CAMS study cancer cannabidiol cannabinoid receptors cannabinoid system cannabis products derived Cannabis sativa cannabis-based medicines CB1 receptors central nervous system chronic pain clinical trials common compressed describe herbal cannabis disability disease dose dronabinol drugs effect of cannabinoids effect of THC endogenous cannabinoids evidence Exogenous flower heads GW Pharmaceuticals herbal cannabis extract herbal cannabis products high densities impairment indoors under optimal inflammatory inhibit Marinol migraine multiple sclerosis muscle nabilone nausea and vomiting nerve neuropathic pain number of patients Numerical Rating Scale obesity oral oromucosal osteoporosis outcome measures patients on placebo patients with multiple peripheral pharmacological placebo placebo-controlled plants grown indoors potency potential progressive multiple sclerosis psychoactive psychosis randomised reduce rimonabant role Sativex side effects significant smoking cannabis spasticity substances synthetic cannabinoids therapeutic tissue tolerance tried cannabis variety Visual Analogue Scale weight loss
Page 31 - Do cannabis-based medicinal extracts have general or specific effects on symptoms in multiple sclerosis? A double-blind, randomized, placebo-controlled study on 160 patients. Mult Scler 10:434-441.
Page 33 - Andreasson S, Allebeck P, Engstrom A, Rydberg U. Cannabis and schizophrenia. A longitudinal study of Swedish conscripts. Lancet 1987 December 26;2(8574):1483-6.
Page 31 - Initial experiences with medicinal extracts of cannabis for chronic pain: results from 34 'N of 1